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《Journal of Isotopes》 2008-04
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Study of Indirect ~(99)Tc~m Labelling NGR-IFN-α2a

REN Bing-xiu~1 WANG Jing~1 ZHANG Lu~2 WANG Zhe~1 YANG Wei-dong~1 ZHANG Ying-qi~2 LI Guo-quan~1 HE Li-qing~2(1.Department of Nuclear Medicine,Xijing Hospital,the Forth Military Medical University of PLA,Xi'an 710032,China;2.Center of Biotechnology,the Forth Military Medical University of PLA,Xi'an 710032,China)  
NGR-IFN-α2a was labelled with ~(99)Tc~m by two-step method used ethylenedicystein as a bifunctional chelating agent and MDP as a medium chelating agent.The bioactivities of EC-NGR-IFN-α2a and ~(99)Tc~m-EC-NGR-IFN-α2a were identified.It showed that the produc- tivity of EC-NGR-IFN-α2a was 87.5%,the labelling yield rate and the radiochemical purity of ~(99)Tc~m-EC-NGR-IFN-α2a was 86% and 96%,respectively.In vitro,the radiotabelled compound had good stability,no bioactivity difference was found among EC-NGR-IFN-α2a, ~(99)Tc~m-NGR-EC-IFN-α2a and NGR-IFN-α2a.
【Fund】: 国家自然科学基金资助项目(30570526)
【CateGory Index】: R817
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 MENG Jie-Ru, YAN Zhen, ZHAO Ning, ZHANG Ying-QiBiotechnology Centre, Department of Pharmaceutics, Fourth Military Medical University, Xi’an 710033, China;High cell density fermentation of engneering E. coli expressing tumor targeted interferon-α2a[J];Journal of The Fourth Military Medical University;2004-23
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Chun, CONG Yan-guang, HU Fu-quan, RAO Xian-cai (Department of Microbiology, College of Medicine, Third Military Medical University, Chongqing 400038, China);Reconstruction of engineered bacteria in preparing recombinant human peptide antibiotic β[J];Acta Academiae Medicinae Militaris Tertiae;2006-22
2 HU Pei-Zhen1,LU Fan2,WANG Xiao-Gong2,LI Xia1,SI Shao-Yan1,HUANG Yang1,MA Bin1,ZHANG Xiu-Min1,SUI Yan-Fang11Department of Pathology, Xijing Hospital, 2Department of MolecularBiology and Biochemistry, School of Basic Medicine, Fourth Military Medical University,Xi’an 710033, China;High cell-density fermentation of engineered E.coli and antitumor immunity of recombinant human MAGE3/HSP70 in vivo[J];Journal of the Fourth Military Medical University;2007-03
3 DUAN Lian,LI Xian - feng (Department of Nuclear Medicine,The First Hospital affiliated to Shanxi Medical University,Taiyuan030001,China);The progressing of studying about nuclide imaging of myocardial apoptosis[J];Foreign Medical Science.Section of Radiation Medicine and Nuclear Medicine;2004-01
4 ZHANG Xin, LI Ya-ming (Department of Nuclear Medicine, The First Hospital Affiliated to Dalian Medical University, Dalian 116011, China; Department of Nuclear Medicine, The First Hospital Affiliated to China Medical University, Shenyang 110001, China);Application and advance of apoptosis ~(99m)Tc labelled annexin V imaging in tumor research[J];International Journal of Radiation Medicine and Nuclear Medicine;2006-04
5 ZHANG Xin1, LI Ya-ming2, ZHANG Yan-jun1, JI Xiao-peng3, TAO Li1, ZHANG Jian-ying4, ZHAO Zhen-zhen4, TIAN Ai-juan3, ZHU Yi1, YANG Chun1, ZHAO Ming3 (1. Department of Nuclear Medicine, the First Hospital Affiliated to Dalian Medical University, Dalian Liaoning 116011, China; 2. Department of Nuclear Medicine, the First Hospital Affiliated to China Medical University, Shenyang 110001, China; 3. Department of Nuclear Medicine, the Second Hospital Affiliated to Dalian Medical University, Dalian Liaoning 116023, China; 4. Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China);Detection of tumor apoptotic response in vivo after a single dose of chemotherapy with ~(99)Tc~m-rh-Annexin Ⅴ[J];Journal of China Clinic Medical Imaging;2007-03
6 ZHANG Xin1,LI Ya-ming1,ZHANG Yan-jun2,LV Guang-yan3,TAO Li2,ZHANG Jian-ying4,ZHAO Zhen-zhen4,ZHU Yi2,YANG Chun2(1.Department of Nuclear Medicine,the First Hospital Affiliated to China Medical University,Shenyang 110001,China;2.Department of Nuclear Medicine,the First Hospital Affiliated to Dalian Medical University,Dalian Liaoning 116011,China;3.Central Laboratory of Dalian Medical University,Dalian Liaoning 116023,China;4.Key Laboratory of Radiopharmaceuticals,Ministry of Education,College of Chemistry,Beijing Normal University,Beijing 100875,China);Distribution of ~(99)Tc~m-rh-Annexin Ⅴ and its relationship with expression of bcl-2,bax in tumor early after radiotherapy[J];Journal of China Clinic Medical Imaging;2007-12
7 ZHANG Xin1,ZHANG Yan-jun1,ZHANG Jian-ying2,JI Xiao-peng3,LI Xue1,ZHU Yi1,YANG Chun1,ZHAO Ming3,TIAN Ai-juan3,LI Ya-ming4 (1. Department of Nuclear Medicine,the First Hospital Affiliated to Dalian Medical University,Dalian Liaoning 116011,China; 2. Key Laboratory of Radiopharmaceuticals,Ministry of Education,College of Chemistry,Beijing Normal University,Beijing 100875,China; 3. Department of Nuclear Medicine,the Second Hospital Affiliated to Dalian Medical University,Dalian Liaoning 116023,China; 4. Department of Nuclear Medicine,the First Hospital Affiliated to China Medical University,Shenyang 110001,China);Distribution of ~(99)Tc~m-rh-Annexin Ⅴ and its relationship with expression of VEGF and Survivin in tumor after a single dose of chemotherapy[J];Journal of China Clinic Medical Imaging;2008-12
8 JIN Cai-ling~1,XU Yu-jie~1,FAN Wo~1,HUA Zi-chun~2,HU Ming-jiang~1,WANG Dao-jin~1,ZHU Ran~1,ZHANG You-jiu~1(1.School of Radiation Medicine and Public Health,Suzhou University,Suzhou 215007,China; 2.State Key Laboratory of Medical Biology Technology,Nanjing University,Nanjing 210093,China);Labeling of Annexin V With ~(125)I and Its Biodistribution in Mice[J];Journal of Isotopes;2005-04
9 ZHANG Xin1, LI Ya-ming1, ZHANG Yan-jun2, JI Xiao-peng3,TAO Li2, ZHANG Jian-ying4,ZHAO Zhen-zhen4, ZHU Yi2, YANG Chun2, ZHAO Ming3, TIAN Ai-juan3(1.Department of Nuclear Medicine, The First Hospital Affiliated to Dalian Medical University, Dalian 116011, China; 2. Department of Nuclear Medicine, The First Hospital Affiliated to China Medical University, Shenyang 110001, China;3.Department of Nuclear Medicine, The Second Hospital Affiliated to Dalian Medical University, Dalian 116023, China;4. Key Laboratory of Radiopharmaceuticals (Beijing Normal University ), Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China);Distribution of ~(99)Tc~m-rh-Annexin Ⅴ in Tumor and Expression Relationship of bcl-2, bax After a Single Dose of Chemotherapy[J];Journal of Isotopes;2007-01
10 SUI Wen-Jun1,2,LIU Yong-Lan1,2,LEI Xiao-Ying1,2,HUANG Qi-Chao1,2, GUO Yan-Hai1,2,WANG Wei1,2,ZHANG Ying-Qi1,2,YAN Zhen1,2 1.State Key Laboratory of Tumor Biology;2.School of Pharmacy,the Fourth Military Medical University; Xi'an 710032,China;Effects of IFN-α2a-NGR Combined with 5-Fluorouracil on the Sensitivity of A549 Cell Line[J];Letters in Biotechnology;2011-03
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 MENG Jieru,YAN Zhen,ZHAO Ning et al (Biotechnology Center, The Fourth Military Medical University, Xi'an 710032);Stability of Biological Characteristics of Recombinant Bacterial Strain Ex-Tumor Targeted IFNα2a[J];Chinese Journal of Biologicals;2003-04
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