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《Journal of Isotopes》 2011-02
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Labeling of NGR Peptide With ~(188)Re and Its Biodistribution and SPECT Imaging in Tumor-bearing Nude Mice

SUO Yao-yu,YANG Wei-dong,MA Xiao-wei,WANG Jing(Department of Nuclear Medicine,Xijing Hospital, Fourth Military Medical University,Xi'an 710032,China)  
To evaluate its radiochemical characteristics,biodistribution and imaging for nude mice bearing HepG2,188Re-NGR was prepared directly with 2-mercapto-ethanol as reductant and sodium gluconate as middle ligand.The labeling yield of 188Re-NGR was more than 85%,and the radiochemical purity(RCP) was more than 90%.In vivo,188Re-NGR can specifically bind with tumor.The tumor uptake was(2.84±0.51)%ID/g at 1 h after injection,the uptake was(4.62±0.71)%ID/g at 12 h and remains(2.01±0.38)%ID/g for 24 h,the contrl group was(1.43±0.61)%ID/g.The ratio of tumor to muscle was 4.76 at 12 h.The xenografted tumor became visible at 1 h and was the most clearly at 12 h.The results showed that NGR had the function of good targeting.
【Fund】: 国家自然科学基金资助项目(30770598 30970846)
【CateGory Index】: R817.9
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