Effect of magnetic fields on human brain microvascular endothelial cell proliferation under normal and hypoxia conditions

MENG Qing-nan;WANG Yun-hua;ZHANG Hao-nan;YANG Lin;WANG Yi-min;Traditional Chinese Medicine Engineering Institute of Tianjin University of TCM;Tianjin University of TCM;  

[Objective] To observe effect of different permanent magnetic fields on human brain microvascular endothelial cell(HBMEC) proliferation under normal and hypoxia conditions. [Methods] HBMEC were cultured in vitro under normal condition and hypoxia condition, experimental cells were divided into 10 groups, control group,ginkgo biloba injection(350 mg/L) group, different induction magnetic field groups(3.4, 5.6, 13.8, 27.8, 52.6, 107.0,178.9, 292.2 mT), each group was collected specimens 48 h after planking, MTT method was used to measure cell proliferation. [Results] Compared with control group, the drug group was statistically different(P 0.05) under normal condition and hypoxia condition, magnetic field groups were no statistically different(P0.05); there was no statistical difference between magnetic field groups(P 0.05). [Conclusion] Magnetic field groups with magnetic induction 3.4,5.6,13.8,27.8,52.6,107.0,178.9,292.2 mT have no effect on proliferation of HBMEC cultured under normal or hypoxia condition.

【Key Words】： permanent magnetic field human brain microvascular endothelial cell cell proliferation
【Fund】： 国家自然科学基金资助项目(30873467)
【CateGory Index】： R363

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