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《Chinese Journal of Gastroenterology and Hepatology》 2009-09
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The significance and expressions of MMP-3 and PPAR-γ in colonic mucosa of rats with UC

KE Xiquan1,WANG Qizi1,YAN Shanjun1,WANG Qiangwu1,LI Dapeng1,YU Donghong21.Department of Gastroenterology;2.Department of Pathology,the First Affiliated Hospital of Bengbu Medical College,Anhui Province,Bengbu 233000,China  
Objective To detect expressions of MMP-3 and PPAR-γ in colonic mucosa of rats with UC,and to explore the role of them in the carcinogenesis of UC. Methods Compound method was used to make models of rats with UC.Expressions of MMP-3 and PPAR-γ in colonic mucosa of rats in model group and control group were detected by immunohistochemical Elivision method,and the relationship with histopathologic stage was analyzed. Results The positive expression rates of MMP-3 in colonic mucosa of model group and control group were 90%(18/20) and 55%(11/20) respectively,the expression of MMP-3 in colonic epithelium of model group was significantly higher than that in control group,the difference was significant(P=0.013).The expressions of MMP-3 in three stages(Ⅰstage,Ⅱstage,Ⅲstage) of rats with UC were 74.79±7.75,88.07±7.05,98.77±6.87 respectively;there were significant differences among three stages.The positive expression rates of PPAR-γ in colonic mucosa of model group and control group were 35%(7/20) and 80%(16/20),there was significantly different between them(P=0.004).The expressions of PPAR-γ in three stages(Ⅰstage,Ⅱstage,Ⅲstage) of rats with UC were 74.09±13.76,49.25±10.86,11.76±6.12 respectively;there were statistical differences among them(P0.05).There was a negative correlation between the expressions of MMP-3 and PPAR-γ in colonic mucosa of rats with UC(rs=-0.454,P=0.044).MMP-3 in colonic mucosa of rats with UC was over expressed,and it was a positive correlation with the histopathologic stage;PPAR-γ in colonic mucosa of rats with UC obviously decreased,and it was a negative correlation with the histopathologic stage. Conclusion The different expressions of MMP-3 and PPAR-γ may cooperatively play a role in the pathogenesis and development of UC.The combined detection of MMP-3 and PPAR-γ may be a monitoring indicator for clinical diagnosis of UC and assessing the histopathologic stages.
【CateGory Index】: R574.62
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