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《Wuhan University Journal(Natural Science Edition)》 2002-06
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Study on Immunogenicity of Hepatitis C Virus Envelope Protein E1 in Mice and Rabbits

XU Jin-ping 1,2, YE Lin-bai2, MENG Xiao-lin2, SHE Ying-long2, WU Zheng-hui2 (1. College of Life Science and Techology, Huazhong Agricultural University, Wuhan 430070, Hubei,China; 2. Institute of Virology, Wuhan University, Wuhan 430072, Hubei,China)  
To explore the feasibility of using envelope protein E1 of Hepatitis C virus (HCV) as vaccine against HCV, HCV E1 inclusion body expressed inE. coli was used as antigen to study the immune response and safety in mice and rabbits. The E1 protein induced mice and rabbits immunized to produce special IgG antibody to HCV E1. The protein induced distinct increase of the ratio of CD+ 8 T cells of the immunized mice too. It was presumed that the structure of the inclusion body was propitious to immunogen submitting. Suggest that the function of E1 protein that induce immune response has no relevance to protein glycosylation. The results showed that E1 protein with the structure of inclusion body had nice immunogenicity. It provided a basis of developing a kind of effective and universal HCV vaccine.
【Fund】: 湖北省科技厅重点基金资助项目 ( 96 2 90 90 6 )
【CateGory Index】: R392
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【References】
Chinese Journal Full-text Database 1 Hits
1 WANG Guo-qiang1,XING Shan-xia2(1.Department of Clinical Laboratory of the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,China;2.The Infectious Disease Hospital of Xinxiang City,Xinxiang 453000,China);The study on the variance of HCV E protein gene and significance of the variance[J];Chinese Journal of Microecology;2009-01
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 LIAO Xiao-ling, QI Zhong-tian (Department of Medical Microbiology, Second Military University, Shanghai 200433, China);Recent advances in hepatitis C vaccine[J];Immunological Journal;2005-S1
2 YOU Chong Ge,LI Yi Min,BAI Zhi Sheng.The Second Affiliated Hospital of Lanzhou Medical College,Lanzhou Institute of Biological Products,Lanzhou 730030;CTL activity detection of immune response to hepatitis Cviral nucleic acid vaccine[J];Chinese Journal of Immunology;2002-06
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