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《Journal of Wuhan University(Natural Science Edition)》 2015-01
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A Novel Transdermal Drug Delivery System—IbuprofenBacterial Cellulose Membrane

HUANG Fang;HUANG Lin;YANG Guang;Hospital of Huazhong University of Science and Technology;Wuhan East Lake High-Tech Development Zone Administrative Committee;Department of Life Science and Technology,Huazhong University of Science and Technology;  
Bacterial cellulose(BC)was used as the carrier for ibuprofen to produce a controlled release system.Drug release studies and transdermal experiments were carried out in vitro to study its sustained release and transdermal properties.The results showed that:carrier BC could significantly extend the drug release time compared with commercially available ibuprofen tablets;mechanism of drug release was the dual role of the cellulose backbone swelling and the hydrogen between drug molecules and cellulose chains.By screening penetration enhancers,propylene glycol was the best one for promoting drug through BC membrane.As a transdermal formulation carrier,BC released drug at a slow and constant speed,which could both avoid skin stimulation caused by the high concentration of drugs released in a short time,and adjusted the bioavailability of the drug.Therefore,BC had great advantage compared with commercially available ibuprofen gel.
【Fund】: 国家自然科学基金(21074041);; 华中科技大学医工、医理交叉基金(0125170002)资助项目
【CateGory Index】: TQ460.1
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