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《Medical Journal of the Chinese People's Armed Police Forces》 2007-05
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Effects of gypenosides on expression of Jun protein in hippocampus of rats with cerebral ischemia-reperfusion injury

ZHU Tieliang,ZHANG Li,QI Gang,and WANG Chao.Pharmacy of Affiliated Hospital of Chinese People's Armed Police Forces Medical College,Tianjin 300162,China  
Objective To study the inhibitive effect of gypenosides on expression of immediate early gene c-jun in hippocampus of rats with cerebral ischemia-reperfusion injury.Methods Modified Pulsinelli 4vessel occlusion(4-VO) was used to develop the rat model of acute cerebral ischemia-reperfusion.Brain specimens were taken 6 h,24 h,and 72 h after cerebral ischemia-reperfusion injury.ABC immunohistochemical anslysis was carried out to observe the expressions of Jun protein at different times in hypocampus of rats receiving high and low pocampus dosage GP.Results The expression of Jun protein was highes in the model group,compared with the blank group.The expression of Jun protein in hippocampus of experimental groups decreased progressively with increasing time of reperfusion(6 h24 h72 h).The expression of Jun protein in the groups of reperfusion 6 h ranked in the following order: model group high GP dosage group low GP dosage group.Compared with model group,high and low dosage GP groups showed noticeable inhibitive effect on expression of Jun protein in hippocampus at different cerebral ischemia-reperfusion times.Conclusions GP down-regulates the expression of c-jun and inhibits the apoptosis of nerve cells,thus preventing cerebral injury in ischemia-reperfusion rats,and improving the function of impaired nerves;the protective role is related with the dosage of GP.
【CateGory Index】: R285
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Chinese Journal Full-text Database 6 Hits
1 Li Zhenzhou,Wu Weiping,Kuang Peigen.Department of Neurology,General Hospital of Chinese People's Armed Police Forces.Beijing 100039,China;Neuronal apoptosis induced by cerebral ischemia-reperfusion[J];Medical Journal of the Chinese People's Armed Police Forces;2001-03
2 QI Gang,ZHANG Li,WAN Zong-ming, et al .Department of Pharmacology,Medical College of Chinese People′s Armed Police Forces.Tianjin 300162;The changes of nucleic acid in hippocampus and dentate gyrus of vascular dementia rats[J];Acta Academiae Medicinae Cpapf;2000-04
3 QU You-zhi,GAO Guo-dong,LI Yong-lin, et al .(Department of Neurosurgery,Tangdu Hospital,The 4th Military Medical University,710038,China);A study on expression of c-jun protein after focal cerebral ischemia followed by reperfusion and the effects of pharmaceutic interventions[J];Medical Journal of National Defending Forces In Northwest China;2001-01
4 Gang Qi,Central Laboratory of Medical College of Chinese People's Armed Police Force,Tianjin 300162,China Cheng Yang,Department of Anesthesia,Affiliated Hospital of Medical College of Chinese People's Armed Police Force,Tianjin 300162,ChinaLi Zhang,Department of Agent,Medical College of Chinese People's Armed Police Force,Tianjin 300162,China Guang Liang Wu,Department Office,Affiliated Hospital of Medical College of Chinese People's Armed Police Force,Tianjin 300162,China Jie Xiong,Department of Traditional Chinese Medicine,Affiliated Hospital of Medical College of Chinese People's Armed Police Force,Tianjin 300162,China Ji Sheng Li,Institute of Neurobiology,Medical College of Chinese People's Armed Police Force,Tianjin 300162,China;Protective effects of gypenosides on positive neurons of nitric oxide synthase and nucleic acids in hippocampus of rats with vascular dementia[J];Chinese Journal of Clinical Rehabilitation;2004-28
5 ZHANG Li, WU Guang liang, CHEN Xiao yi, QI Gang(Department of Pharmacy, Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China);Protective effect of gypenosides on cerebral cortex and hippocampus in vascular dementia rat[J];Chinese Traditional and Herbal Drugs;2002-04
6 QI Gang, ZHANG Li, XIE Wen-Li, CHEN Xiao-Yi, LI Ji-Sheng(Department of Pharmacology, Medical College of CPAPF, Tianjin 300162, China);Protective effect of gypenosides on DNA and RNA of rat neurons in cerebral ischemia-reperfusion injury[J];中国药理学报(英文版);2000-12
Chinese Journal Full-text Database 10 Hits
1 GAO Shan,KONG Lihong,SU Furong,CHEN Zhenjiang,YAO Shuo (Department of Acupuncture and Moxibustion,Hubei College of TCM,Wuhan Hubei,430061);Effects of Embedding Medicine in Points on Expression of FAS in Hippocampus of Rats with Cerebral Ischemia /Reperfusion[J];Journal of Hubei College of Traditional Chinese Medicine;2008-01
2 QU You-zhi, ZHAO Yan-ling, QIN Huai-zhou,et al.Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China;Effect of astragus injection on apoptosis of neuronal cell and expression of apoptosis-associated genes after cerebral ischemia and reperfusion[J];Nervous Diseases and Mental Health;2007-01
3 ZHANG Hui-li,SONG You-tao,XIN Ru,LI Yu,LIU Hong-sheng (Department of Life Science,Liaoning University,Shenyang 110036,China);The Study on Ultrasound Extraction and Antioxidative Effect of Gypenosides[J];Journal of Liaoning University(Natural Sciences Edition);2006-04
4 WU Jie WEN Tie-qiao Laboratory of Neural Molecular Biology,School of Life Sciences,Shanghai University,Shanghai 200444,P.R.China;Evaluating effects of gypenosides and soyasaponins on differentiation of neural stem cells as an in vitro model[J];上海大学学报(英文版);2008-01
5 QI Gang,ZHANG Li;Progress of Gynostemma on pharmacology[J];Acta Academiae Medicinae Cpapf;2003-03
6 ;Expression of the Bcl-2 protein family and immediate-early genes after cerebral ischemia and their relationship with apoptosis[J];Acta Academiae Medicinae CPAPF;2006-02
7 ZHU Tie-liang,ZHANG Li,QI Gang,HAO Su-yun(Pharmaceutical Preparation Section,The Affiliated Hospital of Medical College of Chinese People′s Armed Police Force,Tianjin 300162,China);The effects of gypenosides on expression of FOS protein on hippocampus in rats after cerebral schemia-reperfusion injury[J];Acta Academiae Medicinae CPAPF;2007-02
8 ZHU Tie-liang,ZHANG Li,WANG Chao,QI Gang(Pharmaceutical Preparation Secton,The Affiliated Hospital of Medical College of Chinese People's Armed Police Force,Tianjin 300162,China);Effects on the expression of JUN protein of gypenosides on dentate gyrus and cerebral cortex in rats after cerebral schemia-reperfusion injury[J];Acta Academiae Medicinae CPAPF;2007-05
9 Lü Jianrui,Ma Hongzhong,Xue Rongliang(Department of Anesthesiology,The Second Affiliated Hospital,Medical School of Xi'an Jiaotong University,Xi'an 710004,China);The expression of c-jun in hippocampus of rats after global cerebral ischemia/reperfusion and the effect of heat shock precondition on it[J];Journal of Xi'an Jiaotong University(Medical Sciences);2006-04
10 You-Zhi Qu,Guo-Dong Gao,Zhen-Wei Zhao,Huai-Zhou Qin You-Zhi Qu,Guo-Dong Gao,Zhen-Wei Zhao,Huai-Zhou Qin,Department of Neuros urgery,Tangdu Hospital,Fourth Military Medical University of Chinese PLA,Xi'an 7 10038,Shaanxi Province,China;Effects of ligustrazine on expression of Bcl-2 and Fas-L proteins after focal cerebral ischemia reperfusion[J];Chinese Journal of Clinical Rehabilitation;2004-16
Chinese Journal Full-text Database 10 Hits
1 SUN Yong-ye,MA Ai-guo,JIA Yi-na,ZHANG Xiu-zhen(Institute of Nutrition ,Medical College of Qingdao University,Qingdao 266021,China);The Effect of Gynostemma Pentaphyllum Extract on DNA Damage of Aging Rats[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-05
2 XU Lu DONG Zhi HUANG Yan(Chongqing University of Medical Sciences,Chongqing 400016);The Experimental Research on Hypnogenetic Effects of Gypenosides[J];;2006-04
3 MA Ting-jun~(1,2),TU Peng-fei~(1*),L Fei-jie~3,HU Xiao-song~3(1 School of Pharmaceutical Sciences,Health Science Center,Peking University,Beijing 100083,China;2 Department of Food Science,Beijing Agricultural College,Beijing 102206,China;3 College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China);Chemical Constituents of Bolbostemma paniculatum[J];Acta Botanica Boreali-Occidentalia Sinica;2006-08
4 WU Hong-jun~1,2,WU Guo-juan~1,DAOFU Xiu-fu~3,CHANG Ze-hong~3(1.Department of Animal Medicine and Science,Beijing Agriculture College,Beijing,102206,China;2.College of Animal Medicine,Xinjiang Agricultrue University,Urumq,Xinjiang,830052,China;3.Mingzhi University College of Agricultrue,Tokyo,Japan);Study on Anti-cancer Effects of Extract from Trichosanthes[J];Progress in Veterinary Medicine;2006-06
5 CAO Ji-hua,WANG Zheng-yi,WANG Qin(Henan College of Traditlonal Chinese Medicine,Zhengzhou 450003,China);Elements in Traditional Chinese Medicine and Healt[J];Trace Elements Science;1999-10
6 Wang Manli Wu Yinghua (Department of Chemical Engineering) Chen Tong (Physical and Chemical Analysis Center);EXTRACT OF GYNOSAPONIN BY COLUMN CHROMATOGRAPHY[J];JOURNAL OF GUIZHOU UNIVERSITY OF TECHNOLOGY;1997-03
7 Xia Lili, Harbin jianer Pharmaceutical Factory(150010);Study on the Biological Effects and Extraction of the Blood Glucose Lowering Active Component from Pumpkin[J];Heilongjiang Medical Journal;2003-04
8 Kong Fan-Hua Zhu Da-Yuan Xu Ren-Sheng~*(Shanghai Institute of Materia Medica, Academia Sinica, Shanghai) Fu Zhang-Cai(Second Hospital of Xi'an Medical University, Xi'an);Studies on the Chemical Constituents of Bolbostemma Paniculatun [Maxim] Franquet Ⅳ. The Structure of Tubeimoside Ⅱ. Ⅲ,and Ⅳ[J];Acta Chimica Sinica;1988-04
9 Zhang Xiaoli Liu Zhen Zhu Ziping Yang Puzhao Xie Renming (Department of Pharmacology, Shanxi Academy of Traditional Chinese Medicine Xi'an 71003);INFLUENCE OF GYPENOSIDES ON THROMBUS AND COAGULATION FUNCTION IN VIVO AND IN VITRO[J];WEST CHINA JOURNAL OF PHARMACEUTCAL SCIENCES;1999-Z1
10 SUN Xiaona,ZHAO Changpu,SUN Junbo,et al Henan Prouincial TCM Hospital,Zhengzhou 450002,China;Clinical Study on Effect of Gynostennae Glycosides Tablets Conjoining Diammonium Glycyrrhizinate Capsules in Treatment of Fatty Liver[J];Journal of Medical Forum;2005-20
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 LIN Shuo,YUE Lin-na,GAO Xue-ling*,YUE Peng-xiang (Key Laboratory of Tea Biochemistry and Biotechnology, Ministry of Agriculture, Ministry of Education, Anhui Agricultural University, Hefei 230036, China);Ultrasonic-enhanced Extraction of Gynosaponins from Gynostemma pentaphyllum[J];Food Science;2009-14
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 Wang Yuanjing,Shen Guoming,Wang qinmao (Department of Combination of Chinese and Western Medicin, Anhui College of TCM,Hefei 230038,China);THE PROTECTIVE EFFECTS OF LIGUSTRAZINE ON ACUTE CEREBRAL ISCHEMIA REPERFUSION INJURY IN RATS[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-01
2 WANG Zhu-Yun, QIU Pei-LunDepartment of Pharmacology, Xi'an Medical University, Xi'an 710061;Protective effect of gypenosides on acute incomplete cerebralischemia in rabbits[J];Chinese Journal of Pharmacology and Toxicology;1992-03
3 Wang Deqing;Shen Wenmei Tian Yaping and Dong Zhennan(Department of Biochemistry,General Hhospital of PLA,Beijing 100853);Protective Effect of Total Flavonoids of Radix Astragali on Mammal ian Cell Damage Caused by Hydroxyl Radical[J];CHINA JOURNAL OF CHINESE MATERIA MEDICA;1995-04
4 XU Danyun , YOU Guoxiong, MIAO Jianting, et al. Department of Neurology, Chinese People's Armed Police Forces, Anhui Provincial Corps Hospital, Hefei 230041;An experimental study of the nitric oxide mechanism in acute cerebral ischemia and during the process of vascular dementia formation[J];CHINESE JOURNAL OF GERIATRICS;1999-04
5 Gao Nannan; Yu Shuren; Lu Ruijian (Institute of Medicinal Plant Development Chinese Academy of Medical Sciences, Beijing 100094);Improving the learning and, memory ability on aging rats by gypenosides[J];CHINESE JOURNAL OF GERONTOLOGY;1995-06
6 Chen Chunfu,Guo Shusu,Feng Lin,et al Department of Neurology,Jinan Military General Hospital,Jinan 250031;Effects of astragus on blood brain barrier and cerebral blood flow during reperfusion of cerebral ischemia in rats[J];SRTOKE AND NERVOUS DISEASES;1998-03
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