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TOXIC EFFECTS OF CADMIUM ON LHRH-INDUCED LH RELASE AND OVULATION IN RATS

Ding Xuncheng et al, ( National evaluation centre for the toxicology of fertility regulating drugs, shanghai 200032 )  
Groups of SD rats were given cadmium chloride ( CdCl2 ) at 5, 10 mg/kg b.w.or 0.9% Nad solution at 1.0 mg/kg subcutaneously on the day of diestrus Ⅱ.Six days later(proe-streus), they were anesthetized with pentobarbital and injected intravenously with 0.5 or 2.0 μg/kg LHRH. Their blood was collected for LH determination. The second batch of the rats pretreated with 10 mg/kg CdCl2 and treated with 4 μg/kg LHRH was allowed to recover from the ansthesia and checked for ovulation on the next day ( estrus ) . In the rats pretreated with 10 mg/kg CdCl2, the LH content of pituitary gland was found reducd remarkably, while those preteated with Cd++, the ovulation was found recovered, which received supplementary LHRH. It is concluded that Cd++-induced anovulation is associated with the altered function of the pituitary gland and ovary, which can restored by excess LHRH.
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