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《Journal of Health Toxicology》 2003-01
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Proliferation of endometrium in mice exposed to endosulfan

YAN Ji\|cheng,ZHU Xin\|qiang,ZHENG Yi\|fan,et al. (Department of Toxicology,Medical College of Zhejiang University,Hangzhou Zhejiang 310031, China)  
Objective To study the proliferative effect of endosulfan on endometrium in mice.Methods The ovariectomized sexual mature female ICR mice were administrated with endosulfan(0\^5,1\^5,3\^0 mg/(kg·d)) through peros for five days.The proliferative effects were evaluated by mitotic index(MI) and argyrophilic nucleolar organizer region\|associated proteins(Ag NORs).Results The medians of MI in the endosulfan treated groups were 3\^0,3\^5 and 4\^75 respectively,which were significantly different from that of negative control( P 0\^01).The means of Ag\|NORs in negative control group,low,medium,high dosage groups,and the positive control group were 2\^12,2\^77,3\^39,3\^88 and 4\^44 respectively.The difference between the three dosage groups and the negative control was significant( P 0\^01).There was definite dose\|response relationship among the three dosage groups in MI and Ag\|NORs.Conclusion Endosulfan can promote DNA transcription and proliferation of endometrial cells in mice,therefore,it is likely to act as an estrogen in vivo.
【CateGory Index】: R99
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