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《MICROBIOLOGY》 1997-01
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GENOMIC ORGANIZATION OF CHINESE HEPATITIS G VIRUS (HGV) AND DISTRIBUTION OF HGV INFECTION IN CHINA

Zhou Yusen; Wang Haitao; He Yuxian; Zhao Huiliu;Wang Huaichun; Chen Wei; Xu Jiag(Institude of Microbiology and Epidemiology, Beijing,100071)(Research Center of Beijing Ditan Hospital , Beijing 10011)  
The full HGV genome from Chinese was cloned and sequenced from the serum of ablood donor in Hebei province of China. The sequence of 9128bp indicatal that it contains a continuous open reading frame (ORF) which could encode a viral polyprotein of 2870 amino acids.The 5' and 3' untranslated regions are 367bp and 147bp, respectively Compared with publishedHGV sequences , Chinese HGV shows 84% ~ 89% identity at the nucleotide, and 91%~ 94% atthe amino .acid, levels.In order to understand the distribution of HGV infections and molecular characteristics ofHGV isolates from China, serum samples were detected by RT- PCR for HGV RNA and.the PCR products,were sequenced. The serum samples were collected from Hebei province, Nanjing, Guangxi andShanghai city, respectively, The results showed that HGV infection existed both in northern andsouthern China. The positive rate of HGV RNA in population with HCV infection was about6.7%, the positive rate. in patients with hepatitis C was 9.6% and the positive rate in blood donorswas 2.2%. The nucleotide identity between the two isolates (Nanjing and Hebei isolate) is 93.7%,while the two isolated showed 86.06~ 92.12% nucleotide identity over the corresponding region ofisolates in America.
【Fund】: “九五”全军医药卫生科学研究基金
【CateGory Index】: R373.21
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