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《Journal of Microbiology》 2005-03
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Significance of Eotaxin Gene Expression in Acute Tracheal Inflammation of Guinea Induced by Sephadex G-{200} Instillation

LIU Xin1, ZHANG Su1, CUI Yi1, WANG Meng-hua1, JIA Ning2, XU Ming-xin3, YANG Xiao-lin4 (1. Teach. & Res. Section of Pathogenic Boil. Shenyang Med. Coll. Shenyang 110034; 2. Dept. of Clinical Lab. Hospital 739, Shenyang 110034; 3. Obstetrics and Gynecology Hospital, Shenyang 110005; 4. Coll. of Basic Med. China Med. Univ. Shenyang 110001)  
Airway of guinea trachea was instilled with Sephadex G-{200} (5 mg/kg) to induce inflammation to study the significance of eosinophils in airway inflammation. Eotaxin gene expression was measured in lung tissue during airways inflammation and then carried out bronchoalveolar lavage (BAL). The results showed that mRNA expression level of eotaxin was elevated obviously (P0.05) with prolongation of Sephadex G-{200} stimulation after pulmonary damage of the induction. Meanwhile amount of WBC in BAL fluid and IL4 in supernatant were also increased {(P0.05).} Methylprednisolone sodium succinate was used to inhibit airway inflammation compared with using NS as control group (P0.05). Therefore, it is simple and practical animal model with tracheal instillation of Sephadex G-{200} to induce airway inflammation, and eotaxin plays an important role in the course of aggregation and activation of inflammatory cells; glucocorticoid drugs can inhibit eotaxin expression effectively.
【CateGory Index】: R562
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