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《Journal of Hygiene Research》 2000-02
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Protection of metallothionein on the peroxidative injury in testis induced by cadmium

Xu Lichun, Wang Shuyi, Zhao Renzheng, Yang Xiaofang, et al. Key Laboratory for Applied Toxicology of Jiangsu Province, Nanjing Medical University, Nanjing 210029,China  
In order to study the protection effect of metallothionein (MT) on peroxidative injury in testis induced by cadmium and to detect the mechanism of reproduction toxicity of cadmium, the SD rats were injected intraperitoneally with different doses of cadmium (0 2,0 4 and 0 8mg/kgBW) for 7 days. The content of MT, the activities of antioxidases and the content of malondialdehyde(MDA) in testis were detected. The results showed that the increase of MT content in the low dose group was not obvious. MT content increased significantly in the 0 4mg/kgBW group, while decreased in the 0 8mg/kgBW group. There was a significant reduction of the activities of superoxide dismutase(SOD) and glutathione peroxidase (GSH Px) in the high dose group. The content of MDA did not change obviously in the low and middle dose groups, but increased significantly in the high dose group. It was concluded that MT might play an important role in protecting testis from oxidative damage. The toxicity of cadmium on male reproduction might be related to the unbalance of anti oxidation system including MT.
【Fund】: 国家自然科学基金! ( No.3 96 4 0 0 0 6 )
【CateGory Index】: R99
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Chinese Journal Full-text Database 7 Hits
1 TANG Xiu-li;WU Rui-qin;LIU Xin-li;School of Biological Engineering,Qilu University of Technology;The Institute of Disease Control and Prevention,Academy of Military Medical Sciences;;Effects of Metallothionein in Cyclophosphamide-Induced Immunosup Pression[J];齐鲁工业大学学报(自然科学版);2015-02
2 WANG Sui-xin,ZHANG Yu-hua,LI Xiang-yang,et al.Langfang Health Vocational College,Langfang,Hebei 065000,China;Research Advances of Toxicity of Heavy Metals to Spermatogenic Cell Correlated[J];环境与健康杂志;2011-04
3 QIU Ji(Office of Scientific Research,Huzhou Vocational& Technological College,Huzhou 313000,China);Review of the Male Reproductive Toxicity by Cadmium[J];湖州职业技术学院学报;2008-03
4 XU Ye,XIN Nan,LIU Jun-wen.(The Center of Healthy Birth & of Beijing Military area,General Hospital,100700);Determination the Pb content for semindal slurrz bz atomy absorb action spectrum[J];中国优生与遗传杂志;2007-09
5 HUANG Min-yi1,2,ZHANG Yu-hui2,DUAN Ren-yan1(1.Depatment of Life Science,Anqing Teacher College,Anqing 246011,China;2.College of Life Science,Shaanxi Normal University,Xi'an 710062,China);Toxic effect of cadmium on testicular microstructure in Rana nigromaculata[J];生物学杂志;2007-02
6 Fu Yequan, He Baoxia, Xu Shiwen (College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030);Investigation on Determination of Cadmium and Observation of Morphology in Liver of Hyline-white Laying Hens with Subchronic Cadmium Toxication[J];中国农学通报;2007-04
7 WANG Wen xiang,LIAO Hui zhen,CAO Jian ping,et al.Department of Nutrition and Health Care,College of Public Health,Fujian Medical University(Fuzhou 350004,China);Study on reproductive toxicity of subchronic cadmium exposure in male rats[J];中国公共卫生;2004-05
Chinese Journal Full-text Database 1 Hits
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2 JIA Chun-sheng,LI Jin-long,XU Shi-wen* Department of Veterinary Medicine, Northeast Agricultural University, Harbin 150030;Effects of Cadmium on Oxidative Stress and Metallothionein of Blood Vessel in Hens[J];生态毒理学报;2007-02
3 Xu Lichun, Wang Shuyi, Zhao Renzheng, Yang Xiaofang, et al. Key Laboratory for Applied Toxicology of Jiangsu Province, Nanjing Medical University, Nanjing 210029,China;Protection of metallothionein on the peroxidative injury in testis induced by cadmium[J];卫生研究;2000-02
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5 BI Ming-yu,LI Jin-long,LI Shu,CHEN Lei,ZHANG Zi-wei,TANG Hong-peng,XU Shi-wen(College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China);The Role of Mitochondria Mediated Apoptosis Pathway in Sertoli-germ Cell Apoptosis Induced by Manganese in Cocks[J];畜牧兽医学报;2010-04
6 DING Jiao,SUN Ying-biao,CHANG Xu-hong,TAN Jiao,ZHAO Na-juan,GAO Jin-xia(Institute of health toxicology,School of public health,Lanzhou University,Lanzhou Gansu 730000,China);Effect of oxidative stress induced by nickel sulfate on mice spermatogonia in vitro[J];毒理学杂志;2010-01
7 GUO Hai,CAI Xiu-lian,WANG Guo-xiu.(Department of Histology and Embryology,Zunyi Medical College,Zunyi 563003,China.);STUDY ON THE APOPTOSIS ROUTE OF SPERMATOGENIC CELLS OF RATS INDUCED BY MANGANESE[J];现代预防医学;2009-21
8 CAI Xiu-lian, GUO Hai,WANG Guo-xiu. Department of Histology and Embryology,Zunyi Medical College,Zunyi,Guizhou 563003,China;Effects of Manganese on the Expression of Caspase-3 and Cytochrome-c in Spermatogenic Cells of Rats[J];环境与健康杂志;2009-04
9 LU Xiang1, CHEN Wei1, SHU Xiao-lin1, CHEN Jun-xi2 (1. Department of Histology and Embryology; 2. Student of 2006 Grade in Nursing Specialty, Zunyi Medical College, Zunyi 563003, China);Effects of Arseniasis on Apoptosis of Spermatogenic Cells of Rat Testis[J];中山大学学报(医学科学版);2009-02
10 CHEN Wei,LU Xiang,SHU Xiao-lin,et al.Department of Histology and Embryology,Zunyi Medical College(Zunyi 563003,China);Effects of arsenic to apoptosis and telomerase reverse transcriptase expression of rat spermatogenic cells[J];中国公共卫生;2008-11
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LI Hong;PAN Xue-feng;LU Xiao-li;Department of Pharmacy,Fujian Health Professional Institute;;Reproductive toxicity of n-hexane gestational exposure in male offspring rats[J];中国公共卫生;2015-07
2 BIAN Xiao-jiao;PAN Shun-ye;HUANG Qin-yi;XU Hui;ZHENG Wang-long;GU Jian-hong;YUAN Yan;LIU Xue-zhong;LIU Zong-ping;BIAN Jian-chun;College of Veterinary Medicine,Yangzhou University;Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses;;Effects of chronic cadmium exposure via drinking on spermatogenesis of male rats[J];中国兽医科学;2014-10
3 Tian Hongyan;Li Zhixin;Xu Ye;Wang Hongjun;Lin Dongjing;Pan Xiaoyan;Jin Yuji;Liu Zhongping;Sun Qi;Department of Histology and Embryology,Jilin Medical College;;Effects of Bu Shen Sheng Jing Tang on apoptosis of spermatogenic cells in lead-treated mice[J];中国男科学杂志;2014-07
4 ZOU Xue-min;XIAO Man-hong;ZHU Le-mei;School of Public Health,Changsha Medical College;;Protective effect of metallothionein on testicular injury in nickel-chromium exposed mice[J];中国公共卫生;2014-10
5 FENG Lei,DAI Xin-peng,ZHANG Jun,LIU Bai-lin,ZHANG Ying-mei(School of Life Sciences,Lanzhou University,Lanzhou 730000,China);Changes of the Locomotor Performance and Activities of ATPase and AChE of Bufo raddei under the Stress of Heavy Metal Pollution[J];四川动物;2012-04
6 FAN Wei,BIAN Zhan-qiang, TIAN Xiang-hong,et al.National Center for Rural Water Supply Technical Guidance,Chinese Center for Disease Control and Prevention,Beijing 102200,China;Investigation of Heavy Metals in Rural Drinking Water in a Province in South China[J];环境与健康杂志;2012-05
7 DENG Yun-Cui,WANG Hui,LI Yan-Hong,ZHU Xiao-Wen,LUO Ming-Ming,WANG Ya-Nan(Fisheries College of Guangdong Ocean University,Zhanjiang,524025);COMBINED EFFECTS OF Cd~(2+) AND Zn~(2+) ON THE FERTILIZATION RATE IN PINCTADA MARTENSII(DUNKER)[J];海洋与湖沼;2012-02
8 HONG Po AO Ning YAN Ping-mei YAN Xiao-yan GAO Jin-hua(Department of biology,Taiyuan nomral university,Taiyuan 030031,China);Effects of genetically modified anti-dwarf mosaic maize on the male reproductive function in SD rats of F1 generation[J];食品工程;2011-04
9 Liu Peng, Chen Hui, Zhao Wenge (College of Life Sciences and Technology, Harbin Normal University, Harbin 150025);Research Advances in Toxicological Effects of Heavy Metal on the Anuran Larvae[J];中国农学通报;2011-17
10 WANG Sui-xin,ZHANG Yu-hua,LI Xiang-yang,et al.Langfang Health Vocational College,Langfang,Hebei 065000,China;Research Advances of Toxicity of Heavy Metals to Spermatogenic Cell Correlated[J];环境与健康杂志;2011-04
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