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《JOURNAL OF HYGIENE RESEARCH》 2000-04
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Regulation effectof curcumin on blood lipids and antioxidation in hyperlipoidemia rats

Wang Shuran,Chen Bingqing,Sun Changhao Departm ent of Nutrition and Food Hygiene,Harbin Medical U niversity,Harbin 15 0 0 0 1,China  
The regulation effects of curcumin on lowering blood lipids and antioxidation were studied in the hyperlipoidem ia model Wistar rats fed with high fat diet for 4weeks.The hyperlipoidemia m odel rats were then separated into four groups:normal diet group,norm al diet+ curcumin(5 g/ kg) group,high- fat diet group and high- fat diet+ curcum in group.The rats were fed with experimental diets for another 4 weeks respectively.The results indicated that curcumin decreased the serum levels of cholesterol and triglyceride and increased the serum level of apolipoprotein A.Curcumin decreased TBA value and improved total antioxidation capability.The activities of SOD and GSH- PX in liver were enhanced.After taking norm al diet for four weeks,the blood fat and cholesterol levels of the hyperlipoidemia rats recovered.Butin the normal diet+ curcumin group,the same results could be found in two weeks.
【Fund】: 黑龙江省教委基金
【CateGory Index】: R589.2
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