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《Journal of Hygiene Research》 2008-06
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The change of certain biochemical indexes and apotosis protein (Fas/Fasl) expression in rat liver of selenium and iodine deficiency

ZHANG Danying,LEI Yanxia,ZHAO Junjie,TAN Wuhong,et al.Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education,Xi'an Jiaotong University,Xi'an 710061,China  
Objective To investigate the effect of selenium(Se) and iodine(I)deficiency on certain biochemical indexes and apotosis protein(Fas/FasL) expression.Method Healthy SD rats were divided into 4 groups at random,including control group,Se deficient group,I deficient group and both Se and I deficient group.The rats in each group were given different man-made feeds containing different levels of Se and I to breed.The second generation rats were chosen as research subjects.The GPX-Px activity and MDA and NO contents and expression of apoptosis protein(Fas/FasL) in liver were determined by chromometry and western blot.Result GPX-Px of rat liver in Se deficient group significantly reduced,MDA and NO content s and expression of apoptosis of Fas/FasL increased.There were no apparent change in GPX-Px activities and NO contents of rat liver in I deficient group,while the contents of MDA and Fas/FasL expressions were much higher.The changes of GSH-Px activities and contents of MDA,NO as well as the Fas/FasL expressions in both Se and I deficiency groups are much higher than those of Selenium and Iodine deficiency groups.Conclusion Se deficiency can cause the decrease of GPX-Px activities of rat liver and the increase of contents of MDA and NO.It can also lead to over expression of Fas/FasL.It seems that I deficiency can enhance the effect of selenium deficiency.
【Fund】: 陕西省卫生厅科研基金项目(No.041728)
【CateGory Index】: R591.1
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