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Effects of selenium and iodine on glutathione peroxidase activity and thyroid hormone metabolism in rats Ⅱ. Effect of selenium and iodine status on thyroid hormone metabolism in rats

Yi Muqing;Xia Yiming;Tian Yuan (Inst.of Nutrition and Food Hygiene,Chinese Academy of Preventive Medicine,Beijing 100050,China)  
Thyroid hormone(TH)metabolism in rats fed diets with various selenium levels and drinking water with two iodine levels was observed. Hepatic and renal type Ⅰ iodothyronine deiodinase(ID Ⅰ) activities and serum T 3 contents among the Se treated groups were significantly different.The differences of thyroid weight,thyroidal peroxidase (TPO)activity, thyroidal iodine content, and renal ID Ⅰ and cerebral type Ⅱiodothyronine deiodinase(IDⅡ)activities between two iodine groups were significant. A good correlation between thyroidal ID Ⅰ activity and serum T3 content in subgroup Ⅰ(No iodine added ) was found.These results suggest that Se deficiency can affect TH metabolism through changing ID Ⅰ activity with resultant reduction in cerebral IDⅡ activity and aggravation of the effect of iodine deficiency. Thyroidal ID Ⅰ seems to play an important role in the maintenance of the circulating T3 level in iodine-deficient rats. Effects of Se and iodine on TH metabolism may be interrelated.
【Fund】: 国家"八五"课题
【CateGory Index】: R151.3
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