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Inhibition of glutamate uptake in rat brain synaptosome by methylmercury

Zhu Weiguo Chen Xuemin Department of Environmental Health,Tongji Medical University,Wuhan 430030, China  
The effect of methylmercury on the glutamate uptake in rat brain synaptosomes were studied in vitro by using a high affinity uptake test.The result showed that methylmercury(1×10 -9 ~1×10 -4 mol/L)could decrease 3H L glutamate uptake in rat cerebral cortex,hippocampus, striatum and cerebellum synaptosome by 0.7%~74.4%,7.5%~91.1%,1.4%~76.6% and 4.4%~77.0%,respectively,in a dose dependent manner,and their IC 50 were 7.9, 3.6, 2.2 and 4.3×10 -6 mol/L,respectively.It suggested that methylmercury could obviously inhibit glutamate uptake in the synaptosomes of rat brain.
【Fund】: 国家自然科学基金
【CateGory Index】: Q593.2,Q593.2
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