THE INFLUENCE OF GYPENOSIDE(GP) ON PLATELET AGGREGATION AND THROMBOSIS
QiGang Li Changlin Ma Jian SuYaMin(Department of Pharmacology,Chinese People's Armed Police Forces Medical College Tianjin 300162)
This paper studied the influence of Gypenoside (GP) on lpatelet aggregation and thrombosis. It was found that GP (ig50mg/kg, 100mg/kg) respectively inhibited rat platelet aggregation in vivo induced by ADP and AA and collagen,and GP(f. c 100μg/ml,200μg/ml) inhibited rabbit platelet aggregation in vitro induced by PAF. Inaddtion, GP (100mg/kg, 200mg/kg) suppressed the experimental cerebral thrombosis in vivo and arteriothrombosis in vitro in rat and reduced the death rate resulted from pulmonary thrombosis induced by A DP(iv) in mice. Meanwhile,all of those effects showed good dose-dependent manner. Those results indicated that GP is a inhibitor of platelet function.