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《Acta Academiae Medicinae CPAPF》 2007-02
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The effects of gypenosides on expression of FOS protein on hippocampus in rats after cerebral schemia-reperfusion injury

ZHU Tie-liang,ZHANG Li,QI Gang,HAO Su-yun(Pharmaceutical Preparation Section,The Affiliated Hospital of Medical College of Chinese People′s Armed Police Force,Tianjin 300162,China)  
【Objective】 To observe the inhibitive effect of gypenosides on expression of immediate early gene c-fos on hippocampus in cerebral ischemia-reperfusion injury of rats.【Method】Modified 4-vessel occlusion(4-VO) method was carried out to establish the model of acute global ischemia-reperfusion.To draw the materials in 3 time after cerebral ischemia-reperfusion injury,the ABC immunohistochemical method were carried out to observe the influence of the expression of FOS protein on two dosage GP in hippocampus and different moment.【Results】The expression of FOS protein in model group increased significantly compared with the blank.The expression of FOS protein in hippocampus of respective groups are decreased gradually along with the incveasing of the time of reperfusion(reperfusion 6 hreperfusion 24 hreperfusion 72 h).Compare to model group,2 dosage group of GP have noticeable inhibitive effect of on expression of FOS protein on hippocampus in different cerebral ischemia-reperfusion time.【Conclusion】The expression of FOS protein decreased significantly in hippocampus in ischemia-reperfusion rats.The expression of FOS protein were decreased gradually in hippocampus of ischemia-reperfusion 6 h,24 h and 72 h groups rats(reperfusion 6 hreperfusion 24 hreperfusion 72 h).GP is able to prevent cerebral injury in ischemia-reperfusion rats,and the protective effects are related with the dosage of GP.
【CateGory Index】: R285.5
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