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《Acta Academiae Medicinae CPAPF》 2007-05
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Effects on the expression of JUN protein of gypenosides on dentate gyrus and cerebral cortex in rats after cerebral schemia-reperfusion injury

ZHU Tie-liang,ZHANG Li,WANG Chao,QI Gang(Pharmaceutical Preparation Secton,The Affiliated Hospital of Medical College of Chinese People's Armed Police Force,Tianjin 300162,China)  
[Objective] To observe the inhibitive efect of gypenosides on expression of immediate early gene c-jun on dentate gyrus and cerebral cortex in rats after cerebral ischemia-reperfusion injury.[Methods]Modified 4-vessel occlu-sion(4-VO)method was used to establish the model of acute global ischemia-reperfusion.To draw the materials in 3 time after cerebral ischemia-reperfusion injury,the ABC immunohistochemical method were carried out to observe the influence of the expression of JUN protein on two dosage GP in dentate gyrus and cerebral cortex and different moment.[Results]The expression of JUN protein in the model group are increased significantly compared with the blank.The excrease of the time of reperfusion(reperfusion 6 hreperfusion 24 hreperfusion 72 h).The rank of the expression of JUN protein in the groups of reperfusion 6 h is the model group the high GP dosage group the low GP dosage group.Compare to model group,2 dosage group of GP have noticeable inhibitive effect of on expression of JUN protein on dentate gyrus and cerebral cortex in different cerebral ischemia-reperfusion time.[Conclusions]GP is able to prevent cerebral injury in ischemia-reperfusion rats,and the protective role is related with the dosage of GP.
【CateGory Index】: R285
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