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《Acta Academiae Medicinae CPAPF》 2007-06
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Effects of HIF-1α on the apoptosis of colorectal cancinoma

ZHAO Duan-yi,QIAN Cong-kuan,JIANG Cong-qing,LIU Zhi-shu(The 2nd Department of Surgery,Hubei Provincial Corps Hospital of Chinese People's Armed Police Force,Wuhan 430061,China)  
【Objective】To explore the expression of HIF-1α,P53 and MDM2 in colorectal cancinoma and their relation to apoptosis.【Methods】A total of 62 cases of colorectal cancinoma tissue were ex amined immunohistochemically for protein expression of HIF-1α,P53 and MDM2.TUNEL-positive cells were counted in these samples as apoptosis index(AI).【Results】The positive rate of HIF-1α,P53 and MDM2 was 46.77%(29/62),61.30%(41/62) and 25.81%(16/62)respectively.P53 and MDM2 had no significant relationship with Duckes stage and differentiation.The AI in HIF-1α(+) or P53(-) tumors was significantly higher than that in HIF-lα(-)or P53(+)tumors(P0.01,P0.05 respectively).The AI in HIF-1α+/P53-group was significantly higher than that in HIF-1α-/P53+ group(P0.01).HIF-1α was positively correlated with AI,negatively with P53(r=0.43,P0.05;r=-0.31,P0.05).AI in MDM2(+) group was significant higher than that in MDM2(-)group(P0.05).AI in MDM2+/HIF-1α-group was low than that in MDM2+/HIF-1α-group(P0.05) MDM2 was negatively related with HIF-1 expression(r=-0.24,P0.05).【Conclusions】It is possible that there is P53-MDM2 pathway which might regulate tumor apoptosis by degenerating HIF-1α in human colorectal cancinoma.HIF-1 gene might play an important role in promoting tumor apoptosis.
【Fund】: 湖北省科技攻关项目(2003AA301C02)
【CateGory Index】: R735.3
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2 WANG Chen,SHI Yu-rong,HU Fan-guo,NIU Rui-fang,HAO Xi-shan (Affiliated Cancer Hospital of Tianjin Medical University,Tianjin 300060,P.R.China);Construction of HIF-1 alpha gene specific short hairpin RNA expressing plasmid and effect on human colon carcinoma cell[J];Shandong Medical Journal;2008-26
3 ZHANG Ze-ping, JIANG Cong-qing. Department of General Surgery,the Affiliated Hospital of Wuhan University of Science and Technology,Wuhan,430064;The Expression of Hypoxia Inducible Factor-1α Gene and its Relationship with Matix Metalloproteinase-2 in Colorectal Adenomas and Colorectal Adenocarcinomas[J];The Practical Journal of Cancer;2008-01
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1 HAO Lang-song,WANG Geng,QIAN Kun,LUO Ting,LI Xiao-jun,WU Xiao-ting~△.Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041,China;HIF-1α Expression and Relationship Involving Tumor Cell Proliferation and Angiogenesis in Human Breast Carcinoma[J];Journal of Sichuan University(Medical Science Edition);2007-01
2 FENG Hong-jie,CHEN Wei-liang,LI Jin-song,PAN Chao-bin.(Department of Oral Maxillofacial Surgery,Hangzhou First People's Hospital,Hangzhou 310006,China);Expression and significance of hypoxia inducible factor-1α in osseous sarcoma of jaws[J];Stomatology;2006-06
3 LI Fan1 YANG Weimin1 YE Zhangqun1(1Department of Urology,TongJi Hospital,TongJi Medical College,HuaZhong University of Science and Technology,Wuhan,430030,China);HIF-1α expression correlates with angiogenesis in bladder cancer[J];Journal of Clinical Urology;2007-04
4 HE Jian-bin, ZHANG Ping, OU Li-wen, WANG Xiao-hua Department of Respiration, First Affiliated Hospital of Nanhua University, Hengyang 421001, P.R.China;Expressions of HIF-1α and P-Selectin induced by Suramin combination with Quercetin in lung adenocarcinoma in mice[J];Chinese Journal of Cancer Prevention and Treatment;2006-11
5 LI XiaDepartment of Carcinoma,the Affiliated Hospital of Qinghai College,Xining 810001,P.R.China;Expressions and clinical significance of VEGF and HIF-1α in invasive cervical carcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2007-11
6 SUN Hong-cheng,QIU Zheng-jun,CAO Jun,LIU Chen,ZHANG Fang,HUANG Ke-jian.Department of General Surgery,Shanghai First People's Hospital,Shanghai Jiaotong University,Shanghai 200080,China;HIF-1 alpha expression in pancreatic cancer tissue and its effect on cell apoptosis[J];Chinese Journal of Pancreatology;2007-02
7 JIANG Hong-yuan,FENG You-ji.Department of Obstetrics and Gynecology, Obstetrics and Gynecologic Hospital of Fudan University, Shanghai 200011,China;Inhibition of hypoxia-inducible factor 1α expression and tumor growth in SKOV3 ovarian cancer model by sirolimus[J];Chinese Journal of Obstetrics and Gynecology;2004-07
8 LUO Jun *, PENG Zhi lan, YANG Kai xuan, WANG He, YANG Hong, DONG Dan dan,YAO Xian ying *Department of Obstetrics and Gynecology, Sichuan Provincial People′s Hospital, Chengdu 610072, China;Relation between the expression of hypoxia inducible factor-1α and angiogenesis in ovarian cancer using tissue microarray[J];Chinese Journal of Obstetrics and Gynecology;2005-01
9 ZHANG Jun-wen , WANG Pi-long Department of Gastroenterology, The First Affiliated Hospital, Chongqing University Medical Sciences, Chongqing 400016,China;Expression of HIF-1α and Its Relationship to Apoptosis and Proliferation in Gastric Cancer Cell During Hypoxia[J];Cancer Research on Prevention and Treatment;2006-09
10 SUN Ping1,DONG Dian-ning2,KONG Bei-hua1(1. Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Ji′nan 250012,China; 2. Department of Vascular Surgery, Shandong Provincial Hospital, Ji′nan 250021,China);Inhibitory effects of angiostatin gene combined with antisense hypoxia inducible factor-1α gene transfection on implanted human ovarian carcinoma in nude mice[J];Chinese Journal of Cancer Biotherapy;2007-04
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 DU Jing1,ZHAO Qiu21.Department of Gastroenterology,Zhejiang Provincial People's Hospital,Hangzhou 310014,P.R.China2.Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R.China;Inhibitory effect of YC-1 on stability and transcriptional activity of HIF-1 in hypoxic human liver cancer cells-HepG-2[J];Chinese Journal of Cancer Prevention and Treatment;2009-05
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