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《Acta Academiae Medicinae CPAPF》 2007-06
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Effects of HIF-1α on the apoptosis of colorectal cancinoma

ZHAO Duan-yi,QIAN Cong-kuan,JIANG Cong-qing,LIU Zhi-shu(The 2nd Department of Surgery,Hubei Provincial Corps Hospital of Chinese People's Armed Police Force,Wuhan 430061,China)  
【Objective】To explore the expression of HIF-1α,P53 and MDM2 in colorectal cancinoma and their relation to apoptosis.【Methods】A total of 62 cases of colorectal cancinoma tissue were ex amined immunohistochemically for protein expression of HIF-1α,P53 and MDM2.TUNEL-positive cells were counted in these samples as apoptosis index(AI).【Results】The positive rate of HIF-1α,P53 and MDM2 was 46.77%(29/62),61.30%(41/62) and 25.81%(16/62)respectively.P53 and MDM2 had no significant relationship with Duckes stage and differentiation.The AI in HIF-1α(+) or P53(-) tumors was significantly higher than that in HIF-lα(-)or P53(+)tumors(P0.01,P0.05 respectively).The AI in HIF-1α+/P53-group was significantly higher than that in HIF-1α-/P53+ group(P0.01).HIF-1α was positively correlated with AI,negatively with P53(r=0.43,P0.05;r=-0.31,P0.05).AI in MDM2(+) group was significant higher than that in MDM2(-)group(P0.05).AI in MDM2+/HIF-1α-group was low than that in MDM2+/HIF-1α-group(P0.05) MDM2 was negatively related with HIF-1 expression(r=-0.24,P0.05).【Conclusions】It is possible that there is P53-MDM2 pathway which might regulate tumor apoptosis by degenerating HIF-1α in human colorectal cancinoma.HIF-1 gene might play an important role in promoting tumor apoptosis.
【Fund】: 湖北省科技攻关项目(2003AA301C02)
【CateGory Index】: R735.3
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1 JIANG Cong-qing , FAN Li-fang , LIU Zhi-su , QIAN Qun , XIA DongDIAO Lu-ming , HE Yue-ming and AI Zhong-li Department of Colorectal Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China (Jiang CQ, Liu ZS, Qian Q, He YM and Ai ZL) Department of Pathology, Medical College of Wuhan University, Wuhan 430071, China (Fan LF, Xia D and Diao LM);Expression levels and significance of hypoxia inducible factor-1 alpha and vascular endothelial growth factor in human colorectal adenocarcinoma[J];中华医学杂志(英文版);2004-10
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