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《Journal of Logistics University of PAPF(Medical Sciences)》 2014-11
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Brain protective effect of Potentilla anserina L and its regulating on the expression of caspase 3 in rats exposed to acute hypobaric hypoxia

YANG Hu;ZHANG Yong-liang;GONG Hai-ying;LI Ling-zhi;GAO Hong-sheng;Department of Pathology Heibei Provincial Corps Hospital of PAPF;  
【Objective】To study the brain protective effect of Potentilla anserina L and its regulating on expression of caspase 3 in rats exposed to acute hypobaric hypoxia.【Methods】78 Male SD rats were randomly divided into control group, acute hypobaric hypoxia group, intervention groups of Potentilla anserina L. alcohol extract [3.6 g·(kg·d)-1, 1.8 g·(kg·d)-1, 0.9 g·(kg·d)-1] and Nimodipine group[0.02 g·(kg·d)-1], and each group with 13 rats. Each group with 13 rats. Pathological and ultrastructural changes in the cerebral cortex were observed respectively by HE staining and transmission electron microscope,the brain water content was determined. RT-PCR,Western blotting and immunohistochemistry assays were used for detecting the caspase 3 m RNA and protein.【Result】Compared with control group,the morphological strcture were improved and the ultrostructure injury were reduced in cortex of rats treated with 3.6 g·(kg·d)-1Potentilla anserina L. alcohol extract. The brain water content reduced significantly. The levels of caspase 3 m RNA and protein were down-regulated obviously. 【Conclusion】Potentilla anserina L. alcohol extract could attenuate cerebral edema caused by hypobaric hypoxia and protect brain from injury. This activity may be related with its effect of down-regulating the expression of casepase 3.
【Fund】: 国家自然科学基金项目(81471823);; 天津市重点项目(12JCZDJC34700);; 中国博士后基金项目(20100470106)
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 QIN Xiao-jing 1 , LI Ling-zhi 2, 3 , LV Qi 4 , YU Bao-guo 5 , YANG Shu-wang 6 , HE Tao 1 , ZHANG Yong-liang 3, 7 1. Department of Pathology, Affiliated Hospital of Logistic University of Chinese People’s Armed Police Forces, Tianjin 300162, China 2. Department of Medicinal Chemistry, Logistic University of Chinese People’s Armed Police Forces, Tianjin 300162, China 3. Tianjin Key Laboratory of Occupational and Environmental Hazard Biomarkers, Tianjin 300162, China 4. Department of Central Laboratory, Logistic University of Chinese People’s Armed Police Forces, Tianjin 300162, China 5. Department of Rescue Medicine, Logistic University of Chinese People’s Armed Police Forces, Tianjin 300162, China 6. Department of Postgraduate, Logistic University of Chinese People’s Armed Police Forces, Tianjin 300162, China 7. Logistic University of Chinese People’s Armed Police Forces, Tianjin 300162, China;Neuroprotection of n-Butanol Extract from Roots of Potentilla anserina on Hypoxic Injury in Primary Hippocampal Neurons[J];中草药(英文版);2012-03
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