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《Chinese Journal of Microcirculation》 2007-01
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Effect of Astragalus Polysaccharides(APS) on the Content of Hepatic Glycogen in Diabetic KKAy Mice

Zou Feng,Ouyang Jingping, Mao Xianqing/Department of Pathophysiology, School of Medicine, Wuhan University, Hubei Allergic And Immune Diseases Related Lab ,Wuhan 430071  
Objective: To examine the potential effects of APS on pathological changes and synthesis of glycogen as well as the expression of Phospho-Glycogen Synthase Ser641 in liver of KKAy mice(DM model) and C57BL/6J mice (control)after injection of insulin. Method: Female KKAy and C57BL/6J mice were separated into four groups randomly: diabetes(DM)group(n=8);Diabetes with APS therapy(DA)group(n=8);control(C)group(n=10) and APS control(CA)group(n=10). Pre- and post- 8 week of APS therapy,body weight, blood glucose level, serum insulin concentration and the content of hepatic glycogen were observed. Insulin sensitivity was identified by the combination of Homa IR index .In addition,the pathological change were observed through microscope. Further analysis on the insulin stimulated serine 641phosphorylation of hepatic GS was performed by western blotting.Results: There were significant increases in body weight, blood glucose level in mice(P0.01) compared with C mice, which were ameliorated by treatment with APS for 8 weeks(P0.01); the content of hepatic glycogen was decreased (P0.01) in DM mice and increased(P0.01)after APS treatment;Insulin stimulated serine phosphorylation of GS was higher in DM mice (P0.01 )compared with C mice and APS treated DM mice(P0.01). Histological features showed hepatomegaly,typical hepatic steatosis and decreased synthesis of glycogen which can be alleviated by APS therapy. Moreover,all the changes mentioned above didn't occur in C mice whether treated with APS or not.Conclusion: APS can significantly decrease the plasma glucose,improve insulin sensititvity,especially protect hepatocyte:APS also can increase the synthesis of hepatic glucogen by decreasing insulin stimulated GS phosphorylation.
【Fund】: 国家自然科学基金(NO:30370673)
【CateGory Index】: R285.5
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