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《Chinese Journal of Microcirculation》 2007-02
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Effect of Ischemic Postconditioning on Mesenteric Microcirculation of Rats Subjected to Small Intestinal Ischemia/Reperfusion Injury

Yao Shutong, Li Yuzhen, Liu Xiuhua, et al/Department of Pathophysiology, PLA General Hospital, Beijing 100853  
Objective: To study the effect of ischemic postconditioning (I-postC) on mesenteric microcirculation of rats subjected to small intestinal ischemia/reperfusion (I/R) injury.Method: Sixty-four male Wistar rats were randomly divided into sham, I/R , I-postC and ischemic preconditioning (IPC) groups. Mesenteric microcirculation,microcirculatory perfusion of small intestinal wall and hemodynamics were measured on 2 h and 12 h after reperfusion, respectively. The degree of small intestine injury was accessed with Hackel’s method.Results: I/R reduced mean arterial pressure (MAP) and dp/dtmax (P0.05 vs sham group), and increased Hackel's score (P0.01 vs sham group). The internal diameter of microvesseles and the blood flow velocity of venules in I/R group decreased significantly (P 0.05 vs sham group) on 2h and 12h after reperfusion. In contrast, I-postC and IPC resulted in a significant decrease in Hackel's score (P0.05 vs I/R group) and increased MAP, dp/dtmax, microvascular diameters and microcirculatory blood velocity (P0.05 vs I/R group). The microcirculatory perfusion of small intestinal wall in I-postC group and IPC group increased by 67% and 91%,respectively (P 0.05 vs I/R group) on 2h after reperfusion. Conclusion: I-postC protects small intestine from I/R injury by improving intestinal microcirculation.
【Fund】: 国家自然科学基金项目(30670822);; 国家自然科学基金重大国际合作项目(30620130111)资助
【CateGory Index】: R363
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