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《Chinese Journal of Microcirculation》 2008-02
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Preparation of Different viscosities Plasma Expander and Their Application in Hemorrhagic Shock

Zhao Lian,You Guoxing,Xu Jing,et al Institute of Transfusion Medicine,Academy of Military Medical Science,Beijing 100850  
Objective:The aim of this study was to prepare plasma expander of different viscosities and to test the effects of them in hemorrhagic shock.Method:We apply sodium alginate and dextran 70 to prepare(HVPE)and low viscosity plasma expander(LVPE).Colloidal osmotic pressure and viscosity of them were tested.Rat models of hemorrhagic shock were made,HVPE and LVPE were used for resuscitation.Mean arterial pressure was monitored and survival time was observed.Systemic hematocrit(Hct),content of hemoglobin(Hb),blood gas,lactate,plasma colloidal osmotic pressure,blood and plasma viscosity were tested.Results:Colloidal osmotic pressure of HVPE and LVPE were 42.5 and 60.1mmHg,respectively.Both of them were non-Newtonial fluid.HVPE show shear thin,while LVPE show shear thick.Survival rate of HVPE and LVPE were 57% and 100% 90 minutes after the resuscitation.The average level of the plasma viscosity of survivals and deaths in HVPE group were 2.37 and 3.54 mPa·s,respectively.PH and base excess(BE)show less improvement in HVPE group compared with LVPE group.Conclusion:Appropriate plasma viscosity in hemorrhagic shock is needed to be investigated,too high plasma viscosity can cause death.
【Fund】: 军队“十一五”青年学者课题(06Q91)
【CateGory Index】: R459.7
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