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《Chinese Journal of Microcirculation》 2012-01
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The Effect of VVI and DDD Pacemaker Implantation on Serum NT-proBNP Level and Left Ventricular Function in Patients with Sick Sinus Syndrome

Xie Jin,Li Xin,Hu Gang,et al Department of Cardiology,Jingzhou Central Hospital of Jingzhou City,Jingzhou 434020  
Objective:To observe the effect of right chamber ventricular pacemaker implantation(VVI) and dual chambers pacemaker implantation(DDD) in patients with sick sinus syndrome(SSS) on serum nterminal pro-B-type natriuretic peptide(NT-proBNP) level and left ventricular function.Method:118 patients with pacemaker implantation were divided into two groups,VVI pacing was performed in 68 patients while DDD pacing in 50 patients.Serum NT-proBNP level,left ventricular ejection fraction(LVEF) and E/A peak value of bicuspid valve blood flow spectra(E/A)were measured before and 3 months after the operation,and the difference were analyzed in statistics.Results:3 months after the operation,the NT-proBNP increased from 128.05±50.16 pg/ml to 381.26±70.22 pg/ml,LVEF decreased from 58.65±3.82% to 42.32±4.42% and B-E/A decreased from 0.98±0.23 to 0.67±0.16 in VVI group(P0.05),but the NT-proBNP,LVEF and E/A had no statistical changes in DDD group.Conclusion:DDD pacemaker implantation has slight effect on the NT-proBNP level and LVEF compared with VVI,so it should be preferred.
【CateGory Index】: R541.74
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