Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《International Journal of Pathology and Clinical Medicine》 2009-04
Add to Favorite Get Latest Update

Ginkgo biloba extract (Ginaton) attenuates acute lung injury induced by lipopolysaccharide in mice

GUO Zhengming1,CHEN Yi2,LIU Huijun2,XIAO Yuequn1,SONG Haipeng1,WANG Zhaozhao1,QU Xiaolin1,LUO Ziqiang2(1.Department of Basic Science,Hunan Traditional Chinese Medicine College,Zhuzhou Hunan 412012;2.Department of Physiology,Xiangya School of Medicine,Central South University,Changsha 410078,China)  
Objective To determine the protective effect of Ginkgo biloba extract (Ginaton) on acute lung injury induced by lipopolysaccharide (LPS) and its protective mechnism in mice.Methods The Kunming mice were randomly allocated into sham,LPS,Ginaton,and Ginaton+LPS groups.LPS was intraperitoneally injected at a dose of 10 mg/kg body weight in the LPS group,along with equal volumes of saline in the sham group.Ginaton+LPS group and Ginaton group were treated with Ginaton (100 mg/kg,intraperitoneally) 2 h prior to the injection of LPS or saline,respectively.The mice were killed 8 h after LPS challenge The bronchoalveolar lavage fluid (BALF) samples were analyzed for the concentration of total protein,lactate dehydrogenase (LDH) activity.The lung samples were taken for histologic evaluation and for determination of wet-to-dry (W/D) lung weight,malondialdehyde (MDA) level,myeloperoxidase (MPO) activity,nitric oxide (NO) level,and inducible nitric oxide synthase (iNOS) activity,as well as immunohistochemistry analysis for iNOS and heme oxygenase-1 (HO-1) protein expression.Results All the indexes except HO-1 in the ginaton group were not significantly different to those in the control group.But lung tissue and BALF showed serious inflammatory changes in the LPS group.Compared with the LPS group,in addition to inflammatory reaction,the changes of protein content and LDH in BALF and W/D,level of MDA and NO,activity of MPO and iNOS in lung tissues were significantly reduced in the Ginaton+LPS group.(P0.05 or P0.01).The expression ofiNOS protein in lung tissues was obvious higher in the LPS group than that of the Ginaton+LPS group (P0.01);however expression of HO-1 in the Ginoton + LPS group was significantly higher than that of the Ginoton group.Conclusion Ginaton can play a protective role against LPS-induced acute lung injury and it may be associated with the up-regulation of HO-1 and the down-regulation ofiNOS expression and activity.
【Fund】: 湖南省财政厅项目;; 教育厅高校科研基金(05C016)~~
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 CUI Yan ru;LIU Hai-yun;QU Fei;Department of Physiology,Jiangxi University of Traditional Chinese Medicine (TCM);Department of Pharmacology,Jiangxi University of TCM;;Peimisine attenuates acute lung injury induced by lipopolysaccharide in mice[J];时珍国医国药;2014-09
2 QU Ying(Department of Neurology,Chongqing Emergency Medical Center,Chongqing 400014,China);Research on treatment effects of Ginkgo Biloba Extract on chronic cerebral circulation insufficiency[J];重庆医学;2010-18
3 ZHAO Shuangping,WU Jiao,GUO Qulian,ZHANG Zhong,YE Zhi(Intensive Care Unit,Xiangya Hospital,Central South University,Changsha 410008,China);Effect of different concentrations of sevoflurane pretreatment on acute lung injury induced by endotoxin in rats[J];中南大学学报(医学版);2010-09
【Citations】
Chinese Journal Full-text Database 3 Hits
1 ;Effects of the Extract of Gingko Leaf Ginaton on Acute Lung Injury Caused by Lipopolysaccharide in Mice[J];中医药导报;2006-08
2 ZHANG Qiujin , SHEN Hong, ZHANG Wei, LI Yinping, LI Tanshi. EmergencyDepartment, General Hospital of PLA, Beijing 100853, China;Effects of combined naloxone and methylprednisolone on nuclear factor-κB expression in the lung in acute lung injury in rats[J];中国危重病急救医学;2005-06
3 GUZhenyong ,LING Yiling,CONGBin ,etal DepartmentofPathophysiology,HebeiMedicalUniversity ,Shijiazhuang 0 5 0 0 17, China;Peroxynitrite mediated acute lung injury induced by lipopolysaccharides in rats[J];中华医学杂志;2000-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Cheng Yumei;Yang Zhou;Shen Feng;Liu Bo;Wang Yahui;Wu Yanqi;Yao Ling;Liu Yuqing;Department of Intensive Care Unit,Affiliated Hospital of Guizhou Medical University;Department of Anesthesiology,Center Hospital of Xiangyang;Department of Intensive Care Unit,Second Affiliated Hospital of Guizhou Medical University;Department of Intensive Care Unit,Zhenjiang Fourth People's Hospital;;Comparison of lung protection for hydrochloric acid or oleic acid induced rat acute respiratory distress syndrome models pretreated with penehyclidine[J];中华危重病急救医学;2018-05
2 Wu Jinfu;Ge Shenghui;Jiang Lihua;Yang Xi;Wang Lijuan;Department of Anesthesiology,Third Affiliated Hospital of Zhengzhou University;Editorial Departement of Chinese Journal of Anesthesiology,Hebei Provincial Institute of Medical Science Information;;Effect of alprostadil on acute lung injury in septic rats[J];中华麻醉学杂志;2015-12
3 Zhang Hui;Yu Peng;Zhang Nan;Liu Weiqiao;Wang Yao;Changchun University of Chinese Medicine;;Acteoside attenuates acute lung injury induced by lipopolysaccharide in mice[J];中药药理与临床;2015-03
4 Zhang Tianzhu;Yang Shihai;Zhao Lei;Zhang Jinglong;Changchun University of Chinese Medicine;Jilin Agricultural University;;Ziqi water extract attenuates acute lung injury induced by lipopolysaccharide in mice[J];中药药理与临床;2015-02
5 Zhang Bin;Yao Yongxiu;Peng Yuhong;Yuan Ye;Department of Pharmacy & Laboratory,Ya'an Vacational College;;Evodiamine attenuates acute lung injury induced by lipopolysaccharide in mice[J];中药药理与临床;2014-06
6 ZHANG Tian-zhu;ZHANG Jing-long;HAO Bin-bin;XU Jiang;Changchun University of Chinese Medicine;;Lycium chinense Water Extract Attenuates Acute Lung Injury Induced by Lipopolysaccharide in Mice[J];中国实验方剂学杂志;2014-22
7 Zhang Tianzhu;Yang Shihai;Zhang Jinglong;Changchun University of Chinese Medicine;Jilin Agricultural University;;Sangjuyin attenuates acute lung injury induced by lipopolysaccharide in mice[J];中药药理与临床;2014-05
8 SUN Xue-feng;WANG-Jian;YANG Lin;WANG Zheng;Department of Thoracic Surgery,Shenzhen People's Hospital Affiliated to Jinan University;;Influence of transcription factors RORγt on the balance of Th17/Treg in mice with acute lung injury[J];海南医学院学报;2014-04
9 Zhang Tianzhu;Ma Chunhua;Fan Xiangzhe;Changchun University of Chinese Medicine;China Pharmaceutical University;;Naringenin attenuates acute lung injury induced by lipopolysaccharide in mice[J];中药药理与临床;2013-06
10 WANG Weichen1 XIA Yongfu2 HU Yejia1 1 Department of Pathophysiology,Binzhou Medical University,Yantai 264003; 2 Department of Respiratory Medicine,Affiliated Hospital of Binzhou Medical University;Expression and significance of macrophage migration inhibitory factor in ARDS induced in intestinal ischemia-reperfusion[J];滨州医学院学报;2012-05
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Wang Lisha,Mei Mei(Department of Outpatient Clinic of Division of Agriculture,Jilin University,Changchun 130062);Geniposide Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice[J];中国农学通报;2012-23
2 ZHANG Bin1,LI Hong-mei2,WANG Yuan2,WANG Fa-qiang2,WANG Yi-yang2,Lü Xiu-xiu2,QI Ren-bin2,LU Da-xiang2,WANG Hua-dong2(1Department of Cardiothoracic Surgery,The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 519000,China;2Department of Pathophysiology,Key Laboratory of State Administration of Traditional Chinese Medicine,School of Medicine,Jinan University,Guangzhou 510632,China.);Paeoniflorin attenuates LPS-induced acute lung injury in mice[J];中国病理生理杂志;2011-10
3 GUO Zhengming1,CHEN Yi2,LIU Huijun2,XIAO Yuequn1,SONG Haipeng1,WANG Zhaozhao1,QU Xiaolin1,LUO Ziqiang2(1.Department of Basic Science,Hunan Traditional Chinese Medicine College,Zhuzhou Hunan 412012;2.Department of Physiology,Xiangya School of Medicine,Central South University,Changsha 410078,China);Ginkgo biloba extract (Ginaton) attenuates acute lung injury induced by lipopolysaccharide in mice[J];国际病理科学与临床杂志;2009-04
4 LI Jian-jun1,ZHANG Xiao-Lei2,WANG Xiao-shan2,SUN Qi2,ZHANG Ling-ru2 (1.Department of Neurology,Tianchang People's Hospital,Tianchang Anhui 239300;2.Department of Neurology,Nanjing Brain Hospital,Nanjing Medical University,Nanjing Jiangsu 210029,China);Influence of Ginkgo Biloba Extract on neural cell apoptosis and ultrastructure in ischemic penumbra after cerebral ischemia/reperfusion in rats[J];蚌埠医学院学报;2008-04
5 XIAO Ge-Lei1, LUO Zi-Qiang2, XIAO Gong1, Li Chen 2, XIONG Xu-Dong3, YANG Ying3, LIU Hui-Jun2 1Grade 2004; 2Department of Physiology; 3Office of Grade 2004, Xiangya School of Medicine, Central South University, Changsha 410078, China;High-density lipoprotein attenuates lipopolysaccharide-induced acute lung injury in mice[J];生理学报;2008-03
6 CHANG Jia-song,WEI Kai-feng,XU De-guo(Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China);Effect of Shengjiang Powder on Expression of ICAM-1 of Lung Tissue Cells in Acute Lung Injury Rats[J];辽宁中医药大学学报;2008-01
7 SUN Yan-hong (?) Yong WANG Jun-ke Department of Anes(?)siology,Frist Affi(?) (?) of (?) Medical University,Shenyang 110001,China;Effects of sevoflurane on endotoxin-induced oxidative stress response of the lungs in rats[J];中华麻醉学杂志;2006-08
8 GU Da-yong,LIANG Bing,TANG Xu-dong,et al.Science Laboratory,Number 401 Hospital of PLA,Shandong Qingdao 266071,China. Clinical Experimental Institute,Chendu Army General Hospital of PLA,Sichuan Chendu 610083,China;A Research on Expression of ICAM-1 and Adhesion to PMN of PMVEC Directly-Induced by LPS[J];中国微循环;2006-01
9 XU Bin, XU Zhong-bao,GAO Feng-ling,et al. (Department of Neurology,Fuxing Hospital affiliated to Capital University,Beijing 100038, China);Diagnostic value of transcranial Doppler ultrasound for stenosis of extracranial internal carotid artery[J];中风与神经疾病杂志;2005-05
10 SUN Yan hong,ZHANG Qian,WANG Jun ke,CUI Yong Department of Anesthesiology,First Affiliated Hospital of China Medical University,Shenyang 110001,China;Effects of sevoflurane on membrane permeability of alveolar capillaries in rats with acute lung injury caused by endotoxin[J];中华外科杂志;2004-16
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Ke Min;Lin Wei;Zeng Shenbao;Xie Dechen;Department of Anesthesiology,Fuzhou Pulmonary Hospital;;Effects of inhalation of sevoflurane at different time on pulmonary function and oxidative stress in patients with one lung ventilation[J];中国基层医药;2017-14
2 MA Jun;HUANG Xiang;KANG Fang;Department of Anesthesiology,Anhui Provincial Hospital Affiliated to Anhui Medical University;;Effect of sevoflurane on lungs oxygenation function in patients undergoing one-lung ventilation[J];安徽医药;2015-10
3 YUAN Qionghua;Department of Traditional Chinese Medicine, Sujiatun District Central Hospital;;Xueshuantong(freeze drying) in Treating Chronic Ischemic Cerebrovascular Disease for 30 Cases[J];中国中医药现代远程教育;2015-16
4 Zhang Hongqin;Zheng Jing;Jiang Chunxiu;Zhang Jing;Chongqing Municipal Third People's Hospital;;Influence of Sevoflurane on Heme Oxygenase- 1 in Patients with One Lung Ventilation during Thoracic Surgical Procedures[J];中国药业;2015-16
5 Hou Linyi;ZHANG Ziqi;Jiang Qin;Zhang Jifeng;Lyn Jieping;Zhang Wenkai;Department of Intensive Care Unit,Second Hospital of Shanxi Medical University;The Fifth Middle School of Taiyuan;Department of Anesthesiology,First Hospital of Shanxi Medical University;;Study of the anti CD14 monoclonal antibody on NF-kappa B(p65) of alveolar macrophage in rat with acute lung injury[J];中华临床医师杂志(电子版);2015-11
6 WEI Lei;YANG Fen;ZHANG Xia;ZHAO Jianhua;Department of Anesthesiology, Suzhou Municipal Hospital,Jiangsu Province;;Effects of sevoflurane postconditioning on expression of TLR4 in rats with acute lung injury induced by lipopolysaccharide[J];南通大学学报(医学版);2015-03
7 Zhang Hongqin;Xiao Wei;Jiang Chunxiu;Zhang Jing;Department of Anesthesiology,the Third People Hospitals of Chongqing;Department of Thoracic Surgery,the Third People Hospitals of Chongqing;;Effects of different sevoflurane treatments on level of oxidative stress for thoracic surgery patients with one lung ventilation[J];重庆医科大学学报;2015-03
8 Wei Meiliang;Chen Xu;Yuan Jianchun;Department of Anesthesiology,First Affiliated Hospital of Guangxi Medical University;;Effect of sevoflurane preconditioning on intestinal injury in patients undergoing resection for liver cancer[J];中华麻醉学杂志;2014-11
9 Zhang Hongqin;Wang Diping;Li Ping;Xiao Wei;Xu Lu;Department of Anesthesiology,the Third People′s Hospital of Chongqing;Department of Anesthesiology,the First People′s Hospital of Chongqing;;The effect of sevoflurane pretreatment or aftertreatment on intrapulmonary shunt for patients with one lung ventilation during thoracic surgical procedures[J];重庆医学;2014-30
10 LIANG Jianwen;LIU Haiyan;LI Liangchang;XIAO Wen;HE Ziming;The Second People's Hospital of Panyu District, the People's Hospital of Dashi Panyu District;;Curative effect of Ginkgo biloba extract in the treatment of transient ischemic attack[J];中国医药科学;2014-02
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 SUN Ying *,SUN Ren-yu,DU Ye-wei, WANG Shi-wen. *Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China;Protective effect of Ginkgo biloba extract on acute lung injury in aging rats and renal function damage induced by acute lung injury[J];中华老年医学杂志;2004-05
2 GUO Zhenhui,HONG Xin,MAO Baoling,et al. 1Department of Respiratory,Guangzhou General Hospital of Guangzhou Command,Guangzhou 510010;The role of nuclear factor-κB activation in acute lung injury induced by sepsis[J];中国危重病急救医学;2000-06
3 GUZhenyong ,LING Yiling,CONGBin ,etal DepartmentofPathophysiology,HebeiMedicalUniversity ,Shijiazhuang 0 5 0 0 17, China;Peroxynitrite mediated acute lung injury induced by lipopolysaccharides in rats[J];中华医学杂志;2000-01
4 LING YI-LING AND SHAN-SHENG(Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017)WANG LE-FENG,ZHANG JUN-LAN WAN MEI AND HAO RONG-LI;CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8)REVERSES EXPERIMENTAL ENDOTOXIN SHOCK[J];生理学报;1996-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved