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《Journal of Wenzhou Medical College》 2010-03
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Impact of sevoflurane and propofol anesthesia on intrapulmonary shunt and arterial oxygenation during one-lung ventilation

NI Jianwu,YANG Tao,ZHANG Xuezheng,FANG Xiangyu,JIANG Liuming,WU Hui.Department of Anesthesiology,Wenzhou Eighth People Hospital,Wenzhou,325000  
Objective:To compare the effects of sevoflurane and propofol on oxygenation and intrapulmonary shunt during in one-lung ventilation(OLV) at the similar anesthesia depth,with their administration to maintain bispectral index(BIS) values between 40 and 60.Methods:Eighty patients scheduled for a lobectomy,receiving an epidural administration of ropivacaine,were randomly assigned to Group S(maintenance with sevoflurane) or Group P(maintenance with propofol).Took nine time points after placement of a double-lumen tube,arterial and right atrium blood gas samples were taken,hemodynamic parameters and the associated cilinical data were recorded during TLV and the first 40 min of OLV.Results:During the period compared to TLV,the mean PaO2 of the two groups were decreased in OLV(P 0.05)h,owever,no statistical differences were observed between the two groups(P 0.05).The intrapulmonary shunt of two groups was increased during OLV(P 0.05),but the intrapulmonary shunt of Group S was more obvious than that of the Group P(P 0.05).Conclusion:Lower concentration of sevoflurane and propofol increases intrapulmonary shunt during OLV,sevoflurane increased intrapulmonary shunt is more obviously than that of propofol,and they have similar effects on mean PaO2 during OLV.
【CateGory Index】: R614.2
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