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《Journal of Wenzhou Medical College》 2011-05
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Effects of p38MAPK signal transduction pathway on viral myocarditis

WANG Dan,JIANG Jianbin,CHEN Qi,CHU Maoping,QIAN Yan.Department of Pediatrics,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou,325000  
Objective: To observe the change of p38MAPK signal transduction pathway in murine viral myocarditis model,and to further demonstrate its possible mechanism.Method: A total of 75 inbred male Balb/C mice of 4~6 weeks were divided into two groups: myocarditis group(n =60)and control group(n =15).Western blot were used to analyze the contents of phosphorylated p38MAPK in myocardium.Myocardial histopathlolgic changes and concentrations of cardiac troponin I(cTn-I) were observed.Results: The content of phospho-rylated p38MAPK increased on the first day after infection,peaked on the third day,then decreased to the normal level.The change of phosphorylated p38MAPK was earlier than the changes of inflam-mation and serum cTn-I.Conclusion: CVB3 infection stimulates p38MAPK signal transduction pathway in myocardial cells,which related to inflammation in viral myocarditis.
【Fund】: 浙江省卫生厅科研基金资助项目(2004A070)
【CateGory Index】: R725.4
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