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《Journal of Wenzhou Medical University》 2014-07
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Observation on curative effect of mycophenolate mofetil on frequently relapse nephrotic syndrome in children

YE Xiaohua;YANG Qing;LIN Ruixia;ZHUANG Jieqiu;LI Changchong;Department of Renal Medicine,the Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University;Department of Respiration Medicine,the Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University;  
Objective:To observe and evaluate the efficacy and safety of mycophenolate mofetil(MMF)on frequently relapse nephrotic syndrome(FRNS) in children.Methods:Thirty-five patients with FRNS were chosen for observation.Prednisolone was administered 2.0 mg/kg per day and reduced gradually after remission.MMF 20 ~ 40 mg/kg daily in two divided doses after relapse was therefore commenced and this treatment continued for at least 6 months.MMF was abandoned if proved ineffective or continued with a gradually reducing dose if not.Urinalysis,complete blood counts,biochemistry and adverse effects were supervised during the treatmeant.Results:Mean 6-monthly relapse rates decreased significantly from 3.34(2.49,5.50) episodes before MMF therapy to 0.00(0.00,1.00) episodes in the first 6 months in 33 patients(PO.001),from 3.14(2.40,5.00)episodes before MMF therapy to 0.00(0.00,1.00) episodes in the next 6 months in 30 patients(P0.001),from3.34(2.57,6.00) episodes before MMF therapy to 1.00(0.00,1.20) episodes in 13th-18 th month in 23 patients(PO.001),and from 3.34(2.49,6.00) episodes before MMF therapy to 0.60(0.00,1.05) episodes in 17 patients who followed-up for more than 18 months.Prednisolone dosage was tapering during the treatment(PO.001).Adverse effects observed were as the following:one patient had transient abdominal pain,one had got acute appendicitis,two had more cold than usual,one got urinary tract infection and one had a muscle tremor phenomena.No patients were found suffering from hematological abnormalities,impaired renal or hepatic function.Conclusion:MMF is an effective and safe immunosuppressant for children with FRNS.
【CateGory Index】: R726.9
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 YI Zhu-Wen,WU Xiao-Chuan,XU Hong,ZHOU Li-Jun,WU Yu-Bin,FENG Shi-Pin,ZHOU Jian-Hua,YANG Qing,ZHU Guang-Hua,LIU Ai-Min,WEI Min-Jiang,YU Li,ZEN Zhi-Feng.Department of Pediatrics,Second Xiangya Hospital,Central South University,Changsha 4100001,China;A prospective multicenter clinical control trial on treatment of refractory nephrotic syndrome with mycophenolate mofetil in children[J];Chinese Journal of Contemporary Pediatrics;2008-05
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【Co-citations】
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1 YANG Wei-wei,ZHANG Xiao-bo,JI Xiao-qi,ZHANG Li-qin (Department of Nephrology,Huai’an First People’s Hospital Affiliated to NJMU,Huai’an 223300,China);Meta-analysis on the efficacy and safety between mycophenolate mofetil and cyclophosphamide in the treatment of refractory nephrotic syndrome[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2010-08
2 YAO Yong, YANG Ji-yun;Progress in the clinical research of 2008 into urinary diseases in pediatrics in China[J];Chinese Journal of Practical Pediatrics;2009-05
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1 Lei YIN,Harley Robert POWELL,Wei ZHOU.Department of Pediatrics,Shanghai Children′s Medical Center,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200127,China;Therapeutic effect of vincristine on steroid-dependent nephrotic syndrome[J];The Chinese Journal of Contemporary Pediatrics;2005-06
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