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《Journal of Xi'an Jiaotong University (Medical Sciences)》 1987-02
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Zhao Dongke (Department of Pharmacology)  
The influence of DL-tetrahydropalma- tine (DL-THP) and L-tetrahydropalma- tine(L-THP) on the electrocardiogram (ECG) were studied in rats.DL-THP and L-THP were found to decrease the heart rate,to cause P wave to become lower or reversal,or to disappear,and to prolong P-R intervals (P0.01),Q-T intervals and Q-Te intervals (P0.01) .But it did not influence QRS complex wave and R wave.The changes of the ECG induced by THP are similar to those induced by ver- apamil,but dissimilar to those induced by quinidine.The above experimental results demonstrated further that the mechanism of the effect of DL-THP and L-THP on arrhythmia and the infJuence of them on the electrocardiogram might be related to antagonize to calcium.
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