PHARMACOKINETICS AND PHARMACODYNAMICS OF DL-TELRAYDROPALMATINE IN RABBITS
Han Zhenhua, Niu Xiaolin (Dept.of Internal Medicine,Second Affiliated Hospital)
We observed the effect of dl telrahydropalmatine vein preparation on His bundle electrogram in rabbits, in the meantime,dl THP plasma concentration level was determined by a high perpormance liguid chromatography techinique.It was demonstrated that pharmacodynamics of dl THP and the change of this effect in different plasma concentration of dl THP as time possed on .The results showed that A-H interval was lengthened obviously after giving dose in a dose dependent manner while pharmacodynamics and concentration changes were linear correlation( r max =0.9563,r min =0.9473). Significant difference was found between drug and control group (P0 05).But it had no influence on his bundle electrogram H-V interval.The dl THP is an effective drug for treatment of supraventricular tachycardra without obvious advers reaction.
【CateGory Index】： R969