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《Journal of Xi'an Medical University(Chinese)》 2001-04
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Cervical carcinoma cell apoptosis and the expression of Fas and Fas ligand in human being

Zhu Qing,Han Suxia,Li Mingzhong,et alDe partment of Oncology Radiation Therapy, First Hospital of Xi'an Jiaotong Univer sity,Xi'an 710061,China  
ObjectiveTo investigate the expression of F as and Fas ligand and their relationships with apoptosis in human cervical carcino ma.MethodsThe immunohistochemical staining method and SP me thod were used to investigate the expression of Fas and Fas ligand in 47 cases o f cervical carcinoma, 16 cases of cervical interaepithelial neoplasia, 10 cases of chronic cervicitis and 10 cases of normal cervix. TUNEL technique was used to observe the apoptotic cells and the expression of Fas and Fas ligand in 47 case s of cervical carcinoma.ResultsThe expression of Fas and Fas ligand was not only signi ficantly different in different cervix(~{*+~}P~{*+~}0~{*1~}01),but also related to the d egree of differentiation; Cervical carcinoma cells apoptosis was also related to the degree of differentiation and clincal stage(~{*+~}P~{*+~}0~{*1~}05). Cervical carcino ma cell apoptosis was significantly higher in Faspositive and FasLpositive t han that in Fasnegative and FasLnegative(~{*+~}P~{*+~}0~{*1~}05).ConclusionThe development of apoptosis in cervical carcinoma h as a promoting regulation function to Fas and Fas ligand expression, gene treatm ent can alter apoptotic abnormality, thus induce apoptosis in cancerous cell exp ressing Fas and Fas ligand.
【CateGory Index】: R737.9
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