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《Journal of Xi'an Medical University(Chinese)》 2003-04
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The protective effect of naloxone on ischemia reperfusion injury in rat brain

Zhang Xiaoqing, Wang Meina, Ma Xiaoya (Department of Clinical Pharmacology, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China)  
Objective To observe the protective effect of naloxone on ischemia reperfusion injury in rat brain. Methods We used the modified Longa method to make the model of focal cerebral ischemia reperfusion injury in rats to study the effect of different doses of naloxone on LDH, CK in serum and on infarct size, neurological deficit scores, injury of brain tissues in the model rats. Results Naloxone decreased neurological deficit scores, brain infarct size and injury of brain tissues, reduced LDH and CK activities in serum in the model rats in dosage dependently. Conclusion Naloxone has a protective effect on rat brain damage induced by focal cerebral ischemia reperfusion.
【CateGory Index】: R743.33
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