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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2005-04
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The protective effect of hyperoxic liquid preconditioning in myocardial ischemia-reperfusion injury in rabbits

Jing Guixia, Wen Jian, Wang Wei (Department of Anesthesiology, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China)  
Objective To study the protective effect of hyperoxic liquid preconditioning in myocardial ischemia-reperfusion injury. Methods Thirty rabbits were randomly divided into three groups: group A undergoing all procedures except ischemia-reperfusion, group C receiving the routine infusion of hyperoxic liquid 15mL/kg for seven days, and group B receiving the routine treatment infusion of saline instead of hyperoxic liquid 15mL/kg. Seven days later, the myocardial ischemic reperfusion model (I/R) was fabricated, ECG and homodynamic index were monitored simultaneously. Plasma MDA and SOD level was assayed before ligation, 30min after ligation and 1, 2, 3h after reperfusion. Results Hyperoxic liquid preconditioning can lower ST segment and improve index of hemodynamics and significantly reduce myocardial infarction size in group C compared with group B((P0.05)). Compared with that in group A, plasma SOD activity decreased gradually and plasma MDA activity increased gradually in group B(P0.05); and these above-discussed index improved in group C. Conclusion Hyperoxic liquid preconditioning can protect rabbit myocardial injury caused by ischemic reperfusion.
【Fund】: 陕西省科技攻关项目(No.2003K10-G81)
【CateGory Index】: R96
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