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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2007-03
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Changes in myocardial enzymes in serum of patients with primary hypothyroidism

Zhang Jin'an1,Yu Zhiyun1,Zhang Jian2,Wang Yu1,Xiao Wanxia1,Dong Baoning1(1.Department of Endocrinology;2.Department of Clinical Laboratory,the First Affiliated Hospital,Medical School of Xi'an Jiaotong University,Xi'an 710061,China)  
Objective To investigate the changes in serum level of myocardial enzymes in patients with primary hypothyroidism and to evaluate the relationship between the level of those enzymes and clinical or experimental parameters.Methods We measured several myocardial enzymes in serum of 108 patients with primary hypothyroidism including 31 cases of Hashimoto's thyroiditis,28 cases of atrophic thyroiditis,24 cases of Graves' hyperthyroidism treated by 131I,and 25 cases of Graves' hyperthyroidism treated by antithyroid drugs,as well as 50 normal controls.Results All the myocardial enzymes,including creatine kinase(CK) and its isoenzyme CK-MB,aspartate aminotransferase(AST),lactate dehydrogenase(LDH) and its isoenzyme HBDH,especially CK,were elevated in serum of patients with hypothyroidism.In addition,significant negative correlations were found between CK and FT3,CK and FT4,CK-MB and FT3,CK-MB and FT4.No difference in enzyme level was found among different hypothyroidism groups.Conclusion Hypothyroidism may cause elevation of myocardial enzymes in serum of the patients.The degree of CK and CK-MB increase was associated with the severity of hypothyroidism,and thus can be regarded as indexes to determine the severity of hypothyroidism.
【CateGory Index】: R581.2
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHOU Quan 1, LI Zhi Liang 2, WANG Su Hua 2, LU Qing 2 1Department of Cardiovascular Disease, Chinese PLA 451 Hospital, Xi'an 710054, China, 2Department of Cardiovascular Disease, Zhujiang Hospital, First Military Medical University, G;Effect of thyroid function on cardiomyocyte apoptosis in rats[J];Journal of The Fourth Military Medical University;2001-15
2 ZHANG Min LIQin LIQiong (General Hospital of Shuicheng Steel Group Ltd.Company,Liupanshui,Guizhou 553028,China);Misdiagnsic Analysis of 14 Cases of Hypothyroidism[J];Clinical Medical Journal of China;2005-05
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 Gao Yanyan,Xu Hua,Jiang Dongqing;Relation between thyroid function and myocardial enzymes in patients with primary hypothyroidism[J];Shandong Medical Journal;2003-13
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Jin′an, WANG Yili, LUO Wentian, SHI Bingyin, ZHU Benzhang, SI Lüsheng *. * Department of Immunopathology, Xi′an Jiaotong University, Xi′an 710061, China;Antigen receptor Vβ gene usage of T lymphocytes in diseased thyroids in patients with autoimmune thyroid diseases[J];Chinese Journal of Pathology;2001-04
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