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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2008-04
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Effects of ischemic postconditioning on intestinal mucosa mitochondrion after ischemia-reperfusion injury in rat intestine

Chu Weiwei1,Wu Buqiang2,Sha Huanchen3,Wang Dianhua4(1.Department of Pathology,Xi'an Medical College,Xi'an 710021;2.Department ofGeneral Surgery,the Affiliated Heping Hospital of Changzhi Medical College,Changzhi 046000;3.Department of Hepatobiliary Surgery,the First Affiliated Hospital,Medical School ofXi'an Jiaotong University,Xi'an 710061;4.Yunnan Pharmacological Laboratory ofNatural Products,Kunming Medical College,Kunming 650031,China)  
Objective To investigate the effects of ischemic postconditioning (I-post) on intestinal mucosa mitochondrion after ischemia-reperfusion (IR) injury in rat intestine.Methods By using rat model of intestine IR injury,male Sprague-Dawley rats were divided into 4 groups:sham-operation group (S),IR group (IR),ischemic preconditioning group (IPC),and I-post group.Intestinal mucosa mitochondrial ultrastructural changes were observed by using transmission electron microscope (TEM).Mucosal cellular mitochondrial respiration function was studied by measuring the mitochondrial dehydrogenase-dependent reduction of MTT to its formazan derivative,and intestinal mucosal mitochondrial membrane potential was detected by confocal laser scanning microscopy.Results Compared with that in IR group,the injury of mitochondrion in I-post group and IPC group began to recover.The mitochondrial respiratory function and the mitochondrial membrane potential were significantly improved in I-post group and IPC group (P0.05).There were no significant differences between I-post group and IPC group (P0.05).Conclusion The mechanism of ischemic postconditioning against IR injury of intestine in rats is partly related to maintaining the mitochondrial ultrastructural changes and respiratory function and improving mitochondrial membrane potential.
【CateGory Index】: R656.7
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Chu Weiwei,Wu Buqiang,Sha Huanchen,Wang Dianhua(Yunnan Pharmacological Laboratory of Natural Products,Kunming Medical College,Kunming 650031,China);The role of ischemic postconditioning on intestinal mucosa in rats with ischemia-reperfusion injury[J];Journal of Xi'an Jiaotong University(Medical Sciences);2007-02
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 SHA Huan-chen,MA Qing-yong,Rajiv Kumar Jha,MA Zhen-hua Department of Surgery,First Affiliated Hospital,Xi'an Jiaotong University College of Medicine,Xi'an 710061,China;Protective effect of resveratrol on the intestinal mucosal cells in rats with severe acute pancreatitis and the mechanism[J];Journal of Southern Medical University;2008-09
2 LI Zhi-Hui1,2, LI Hui-Min1,LI Bin1,LI Xiao-Jin11Department of Hematology,Yunnan Provincial Second People Hospital,Kunmin 650021,Yunnan Province,China; 2Beijing Daopei Hospital,Beijing 100049,China;Effect of Arsenic Trioxide on Apoptosis in Lymphoblastoid Raji Cell Line with Relation to Expression of Mcl-1 Gene[J];Journal of Experimental Hematology;2009-03
3 CHU Wei-wei1,WU Bu-qiang2,SHA Huan-chen3,ZHANG Run-qi1,YAN Ai-li1,WANG Dian-hua4(1Department of Pathology,Xi'an Medical College,Xi'an 710021,China;2Department of General Surgery,The Affiliated Heping Hospital of Changzhi Medical College,Changzhi 046000,China;3Department of Hepatobiliary Surgery,The First Affiliated Hospital,Medical School of Xi'an Jiaotong University,Xi'an 710061,China;4Yunnan Pharmacological Laboratory of Natural Products,Kunming Medical College,Kunming 650031,China.);Ischemic postconditioning attenuates ischemia/reperfusion-induced intestinal mucosal apoptosis by inhibiting the mitochondrial signaling pathway in rats[J];Chinese Journal of Pathophysiology;2009-01
4 YAO Shu-tong,ZHAO Xiu-mei,LIU Xiu-hua.Dept.of Pathophysiology,PLA General Hospital,Beijing 100853,China;ICAM-1 Inhibition Involving Small Intestinal Protection Induced by Ischemic Postconditioning in Rats[J];Journal of Chinese Microcirculation;2008-02
5 LIU Ke-xuan1,LI Yi1,LI Yun-sheng1,LIU Jia-xin1,HUANG Wen-qi1,WU Wei-kang2 1Department of Anesthesiology,The First Affiliated Hospital,2Institute of Integrative traditional Chinese and Western Medicine,Sun Yat-sen University,Guangzhou 510080,China;Intestinal ischemic postconditioning attenuates acute lung injury induced by intestinal ischemia/reperfusion in rats[J];Chinese Journal of Pathophysiology;2009-09
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 DUAN Dongxiao 1), ZHANG Guihong 1),XING Yin 1), GAO Xiaoqun 2), RU Liqiang 2) 1)Department of Physiology, Medical College, Zhenzhou Universty,ZhengZhou 450052 2)Department of Neurobiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030;Effect of hypoxic pretreatment on expression of hypoxic-inducible factor-1α in transient focal cerebral ischemia rats[J];Journal of Zhengzhou University(Science Medical);2004-06
2 Jing Guixia, Wen Jian, Wang Wei (Department of Anesthesiology, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China);The protective effect of hyperoxic liquid preconditioning in myocardial ischemia-reperfusion injury in rabbits[J];Journal of Xi'an Jiaotong University(Medical Sciences);2005-04
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