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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2008-04
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Effects of ischemic postconditioning on intestinal mucosa mitochondrion after ischemia-reperfusion injury in rat intestine

Chu Weiwei1,Wu Buqiang2,Sha Huanchen3,Wang Dianhua4(1.Department of Pathology,Xi'an Medical College,Xi'an 710021;2.Department ofGeneral Surgery,the Affiliated Heping Hospital of Changzhi Medical College,Changzhi 046000;3.Department of Hepatobiliary Surgery,the First Affiliated Hospital,Medical School ofXi'an Jiaotong University,Xi'an 710061;4.Yunnan Pharmacological Laboratory ofNatural Products,Kunming Medical College,Kunming 650031,China)  
Objective To investigate the effects of ischemic postconditioning (I-post) on intestinal mucosa mitochondrion after ischemia-reperfusion (IR) injury in rat intestine.Methods By using rat model of intestine IR injury,male Sprague-Dawley rats were divided into 4 groups:sham-operation group (S),IR group (IR),ischemic preconditioning group (IPC),and I-post group.Intestinal mucosa mitochondrial ultrastructural changes were observed by using transmission electron microscope (TEM).Mucosal cellular mitochondrial respiration function was studied by measuring the mitochondrial dehydrogenase-dependent reduction of MTT to its formazan derivative,and intestinal mucosal mitochondrial membrane potential was detected by confocal laser scanning microscopy.Results Compared with that in IR group,the injury of mitochondrion in I-post group and IPC group began to recover.The mitochondrial respiratory function and the mitochondrial membrane potential were significantly improved in I-post group and IPC group (P0.05).There were no significant differences between I-post group and IPC group (P0.05).Conclusion The mechanism of ischemic postconditioning against IR injury of intestine in rats is partly related to maintaining the mitochondrial ultrastructural changes and respiratory function and improving mitochondrial membrane potential.
【CateGory Index】: R656.7
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