Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Xi'an Jiaotong University(Medical Sciences)》 2009-05
Add to Favorite Get Latest Update

Relationship between the expression of PTEN mRNA and protein in human brain glioma

MENG Xi-jun1,LIU Yong2,WANG Mao-De1,XIE Wan-Fu1 (1.Department of Neurosurgery,the First Affiliated Hospital,Medical School of Xi'an Jiaotong University;2.Department of Anatomy and Histoembryology,Medical School of Xi'an Jiaotong University,Xi'an 710061,China)  
Objective To explore the clinical significance of the differential expression of PTEN in glioma tissue.Methods The mRNA and protein expressions of PTEN were assayed by reverse transcription polymerase chain reaction(RT-PCR) and immunohistochemistry in 75 human brain glioma cases.Results The positive expression rate mRNA of PTEN differed significantly between brain glioma tissue and normal brain tissue(χ2=22.66,P0.01);the expression of PTEN was significantly higher in well-differentiated glioma than in poorly differentiated glioma.Along with the increase of glioma malignancy level,the expression intensity of PTEN decreased.Conclusion The decrease of the expression of PTEN mRNA and protein may have a very important effect on development and growth of glioma.It could be helpful in predicting the biological behavior and prognosis of glioma.
【CateGory Index】: R739.4
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved