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《Chinese Journal of Cellular and Molecular Immunology》 2008-08
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Expression of p27 and TGF-β in rat kidney with unilateral ureteral obstruction and the relationship between TGF-β and p27

SUN Jian1,TAO Li-jian1,NING Wang-bin1,JIN Ou2,LIU Ji-shi1 1Department of Nephrology,Xiangya Hospital;2Department of Pathology,Basic Medical College,Central South University,Changsha 410008,China  
AIM: To explore the expression of p27 and the changes of TGF-β in the renal tubule on the process of renal interstitial fibrosis caused by unilateral ureteral obstruction(UUO) in rats and to investigate the relationship between TGF-β and p27 in renal interstitial fibrosis rats.METHODS: Sixty rats were randomly divided into sham-operated group(SOR) and UUO group.Ten rats from each group were sacrificed on days 7,14 and 21 after operation respectively.The renal pathological changes were dynamically observed by HE.The expression and dynamic changes of p27 were detected by immunohistochemistry.The levels of p27 mRNA and TGF-β mRNA were detected by RT-PCR.RESULTS: The expression of p27 in renal tubular epithelial cells and p27mRNA was strongly positive in SOR group.With the aggravation of interstitial fibrosis,the expression of p27 gradually decreased in UUO group while the expression of TGF-β increased.There was a negative correlation between TGF-β and p27.CONCLUSION: P27 is involved in the fibrosis of renal mesenchyme in rats with UUO.The mechanism of TGF-β accelerating fibrosis may relate to the reduction of p27 expression in UUO rats.
【CateGory Index】: R692
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