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《Medical Journal of National Defending Forces in Northwest China》 2007-05
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Effect of excess iodine on thyroid function and Trail expression in rats

TIE Li-li,ZHANG Ya-ping,WANG Ying-mei,et al.(Department of Endocrinology,Xijing Hospital,Fourth Military Medical University,710032,China)  
Objective:To investigate the effects of excess iodine on thyroid function and pathologic changes of normal rats.Methods: Female SD rats were feed with high-iodine diets.Immunofluorescence was used to detect the free triiodothyr-onine(FT3) and free thyroxine(FT4) in serum.Semi-quantity RT-PCR,Western-blotting and Immunohistochemical staining were used to detect the expression of Trail in rats.Results: The concentration of FT3 and FT4 increased in the high-iodine group compared to the control group(P0.05).The expression of Trail was observed in thyroid gland of normal rats.Its expression in the high-iodine group was increased compared to the control group(P0.01).Conclusion: The expression of Trail was increased under the induction of excess iodine in rats.The diet with high iodine may induce the apoptosis of thyroid cells by increasing the expression of Trail,and further lead to functional and pathologic changes of thyroid grand.
【Fund】: 陕西省科技攻关课题资助项目(2007K12-02)
【CateGory Index】: R363
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【Citations】
Chinese Journal Full-text Database 5 Hits
1 FU Jian Fang 1, JI Qiu He 1, HUANG Wei Quan 2, ZHANG Nan Yan 1 1Department of Endocrinology, Xijing Hospital, 2Department of Histology & Embryology, Faculty of Preclinical Medicine, Fourth Military Medical University, Xi'an;Expression of TRAIL,DR4 and DR5 in Hashimoto’s thyroiditis[J];Journal of The Fourth Military Medical University;2002-10
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Chinese Journal Full-text Database 10 Hits
1 ;Effects of Increased lodine Intake on Thyroid Diseases[J];China Comtemporary Medicine;2001-02
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