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《Medical Journal of National Defending Forces in Northwest China》 2016-10
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Effect of dexmedetomidine on the injury of non ventilated lung in patients of lung cancer with minimally invasive surgery under general anesthesia

WEN Xiaolin;ZHU Difei;Department of Anesthesiology,the First Affiliated Hospital of Chengdu Medical College;  
Objective:To explore the effect of dexmedetomidine on the injury of non ventilated lung in patients of lung cancer with minimally invasive surgery under general anesthesia.Methods:Fifty-four patients with lung cancer were randomly divided into dexmedetomidine group and control group,27 cases in each group.1μg/kg dexmedetomidine hydrochloride were given by venous pump to patients in dexmedetomidine group 10 min before induction of anesthesia and kept at the 0.5g/(kg·h)transmission rate until the tumors were excised.The same volume of physiological saline was given to control group by venous pump.Lung injury,heme oxygenase 1(HO-1)and hypoxia inducible factor 1α(HIF-1α)were evaluated in all patients at the beginning(Ta),1hour later(Tb)and the end(Tc)of single lung ventilation.Results:Injury scores of the non-ventilated lung in both of the two groups were higher at the Tc than at the Ta.Injury scores of the non-ventilated lung at the Tc were lower in dexmedetomidine group than in control group.HO-1and HIF-1αof the non-ventilated lung in both of the two groups were higher at the Tc than at the Ta.HO-1and HIF-1αof the non-ventilated lung at the Tc were higher in dexmedetomidine group than in control group.Conclusion:Dexmedetomidine can reduce injury of the non-ventilated lung in systemic anesthesia patients with minimally invasive surgery for lung cancer.HO-1and HIF-1αmay be involved in this course.
【CateGory Index】: R614.2;R734.2
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