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《Medical Research and Education》 2010-06
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The Expression of glutathiones transferases-π in the tissue of bladder carcinoma

Qi Lili1,Wei Ruojing1,Fu Weijun2,et al.(1.Department of Urology,the Affiliated Hospital of Heibei University,Baoding 071000,China;2.Department of Urology,General Hospital of PLA,Beijing,100853,China)  
Objective To study the relationship between glutathiones transferasesπ(GST-π) expression in bladder cancer and biological behavior.Methods 147 samples of bladder cancer were determined with immunohistochemistry for the expression of GST-π.Results The expression rate of GST-π was 52.4%(77/147).In the 68 cases with grade Ⅰ the expression rate was 39.7%(27/68);in 49 cases with grade Ⅱ the expression rate was 57.1%(28/49);in 30 cases with grade Ⅲ the expression rate was 73.3%(22/30),in 117 cases with primary bladder cancer the positive expression rate was 57.3%(67/117),in 30 cases with hydroxycamptothecin intravesical recurrence of bladder cancer chemotherapy the positive expression rate was 96.7%(29/30).The results show that the level of GST-π expression in bladder cancer,malignant behavior were closely related to pathological grade(P0.05).Conclusion The results show that the expression of GST-π could reveal the unsuccessful intravesical themotherapy.The expression of GST-π has correlation with the malignant degree and the pathological gradingof bladder cancer.
【CateGory Index】: R737.14
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