Effects of Xinghuayu injection on IL-2 and TNF-α level in serum of tumor-bearing mice

XU Yueqing1,XU Guanghui2,NIU Pei1,BA Weisong2,WANG Jing3,DU Ning4,LI Liping1,LI Juan5,WANG Qian1(1.Health science Center of Hebei University,Baoding 071000,China;2.People’s Hospital of Dingzhou,Dingzhou 071012,China;3.The 252 Hospital of Chinese People's Liberation Army,Baoding 071000,China;4.Baoding Women and Children's Health Hospital,Baoding 071000,China;5.Ltd.Wanjinyangguang of Beijing,Beijing 100038,China)  

Objective To observe the effects of Xinghuayu injection on IL-2 and TNF-α level in serum of tumor-bearing mice.Methods Fourty Kunming mice were randomly divided into 5 groups: model group,three dose Xinghuayu injection groups and cyclophosphamide group.And every mice was subcutaneously injected with hepatoma(H22) cell suspension,and 24 hours later the intraperitoneal injection was done one time a day and it lasted for 7 days.At 24 hours after the last injection,the blood was got in the eyes bare.The serum concentration of IL-2 and TNF-α was determined.Results The serum concentration of IL-2 in both middle and high dose groups of Xinghuayu injection was significantly higher than that of model group(P0.05);The serum concentration of TNF-α in both middle dose and high dose groups of Xinghuayu was significantly higher than that of model group(P0.01).Conclusion Xinghuayu injection can enhance the serum level of IL-2 and TNF-α of tumor-bearing mice.

【Key Words】： Xinghuayu injection hepatoma H22 cell IL-2 TNF-α
【Fund】： 河北省科技厅课题(062761399)
【CateGory Index】： R285.5

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