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《Journal of Northwest A & F University(Natural Science Edition)》 2015-02
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Preparation of compound nanoemulsion of amoxicillin and sulbactam sodium

WU Xiao-li;OUYANG Wu-qing;TANG Jia-xin;College of Veterinary Medicine,Northwest A&F University;  
【Objective】This study investigated the preparation of moxicillin and sulbactam sodiuma nanoemulsion and evaluated its physical and chemical properties.【Method】Nanoemulsion was prepared by the pseudo ternary phase diagram method.In vitro antibacterial activities of nanoemulsions with different ratios of amoxicillin to sulbactam sodium against common pathogenic bacteria of cow mastitis(Staphylococcus aureus,Escherichia coli,and Streptococcus agalactiae)were compared.The optimal ratio of amoxicillin to sulbactam sodiuma was then determined and the physicochemical properties of nanoemulsion with the optimal ratio were analyzed.【Result】The optimal compound amoxicillin and sulbactam sodiuma nanoemulsion consisted of 1%amoxicillin,0.5%sulbactam sodiuma,2.5%cinnamaldehyde,6.25% PEG400,18.75% RH-40,and 71% distilled water.The propotion of amoxicillin to sulbactan sodium was 2∶1.The nanoemulsion particle was spherical with the particle size of 13.41 nm and the polydispersity index(PDI)of 0.188.It had good physical stability.【Conclusion】Amoxicillin and sulbactam sodium nanoemulsion was prepared successfully.
【Fund】: 陕西省重大科技创新专项基金项目(k332020916)
【CateGory Index】: S859.79
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