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《Chinese Journal of AIDS & STD》 2006-04
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Study of HIV infection,co-infection with STDs and HCV and related changes in immunological indicators and viral loads among men who have sex with men in Beijing

ZHANG Xiao-yan,WANG Chen,LI Xin-xu,et al(State Key Laboratory for Infectious Disease Prevention and Control,National Center for AIDS/STD Control and Prevention,China CDC,Beijing 100050,China)  
Objective To elucidate HIV infection and immunity status among men who have sex with men(MSM)in the face of an increasing risk of HIV-1 infection by both hetero-and homo-sexual transmission accounting for 43.6% of overall HIV infection.Method HIV infection was tested among recruited MSM in Beijing and their blood specimens were collected and virus strains were solated and tested.Immunity status including CD~+_4,CD~+_8 T cell counts and viral loads was assayed in those with positive HIV antibodies.Result Of the 526 MSM individnals 17 were confirmed as HIV-1 positive,and the co-infection rates with HCV or syphilis among them were 17.65% and 35.29%,respectively.The amounts of both CD~+_4 T cells and CD~+_8 T cells were significantly decreased in HIV positive cases co-infected with HCV or syphilis,and their viral loads were increased by 6~7 folds accordingly.The circulabng HIV-1 strains isolated in this population group were identified as HIV-1 subtype.In contrast to teports of heterosexual transnission of subtype CRF01-A/E HIV-1 and min cnculaling subtype B/C in China,most of the circnlating virus strains in our study populstion were subtype B,and one was subtype CRF01-A/E.Conclusion Coinfection of HIV with STDs has obviously decreased mmunity against virus replication in MSM population group,and there is a tendency of spreading HIV infections through sex between MSM and other high risk population groups.
【Fund】: 国家“十五”科技攻关课题资助项目(2004BA719A01)
【CateGory Index】: R512.91
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