Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Northwest Pharmaceutical Journal》 2007-04
Add to Favorite Get Latest Update

Determination of telmisartan in human plasma by HPLC with fluorimetric detection and study on its pharmacokinetics

QI Yang-hai1, ZHANG Peng2, LIAN Jiang-ping2, LI Xiao-chuan2, DING Yuan, GU Yi3 (1. Xi'an Qinghua Hospital, Xi'an 710025,China; 2.Department of Pharmacy,The People's Hospital of Shannxi Province, Xi'an 710068,China;3. Department of pharmacy ,Stomatological College, the Fourth Military Medical University, Xi'an 710032,China)  
Objective To establish an HPLC -fluorescence method for quantitative determination of telmisartan in human plasma and to study the pharmacokinetics characteristics of telmisartan tablets in human. Methods 18 male healthy volunteers orally took a single dose of 80 mg tablets. The plasma concentrations of telmisartan were determined by RP-HPLC with fluorescent detector. The determination has been performed on a C18 column ( 250 mm×4.6 mm,5 μm) with acetonitrile-0.1% NH4Ac(40∶60) as mobile phase adjusted pH to 6.5 . The flow rate was 1.0 mL·min-1. The fluorimetric excitation and emission wavelength were set at 315 nm and 365 nm. Results The calibration curve for telmisartan was linear in the range of 2.5 to 750 ng·mL-1(r=0.999 8).The limit of quantitation for telmisartan was 0.5 ng·mL-1 . The pharmacokinetic parameters were as follow : Tmax (1.23±0.37) h;Cmax (485.16±219.28) ng·mL-1;T1/2β (17.24±3.91) h; AUC(0→48) 2 645.41±1 069.74 ng·h·mL-1,respectively. Conclusion The method provides a simple, sensitive, accurate and reliable procedure for determination of telmisartan in plasma.
【CateGory Index】: R96
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 4 Hits
1 ZHANG Jin, CHEN Shao-hang (Ruijin Hospital, Shanghai Second Medical University, SHANGHAI 200025, China);Pharmacokinetics and reasonable clinical application of angiotensin Ⅱ receptor antagonist[J];Chinese Journal of New Drugs and Clinical Remedies;2004-02
2 SHEN Jie,JIAO Zheng, LI Zhong-dong,SHI Xiao-jin,ZHONG Ming-kang (Department of Pharmacy, Huashan Hospital, Affiliated Fudan University, Shanghai 200040);Determination of Telmisartan in Human Plasma by HPLC with Fluorimetric Detection[J];Chinese Journal of Pharmaceutical Analysis;2005-01
3 ZHAO Xia, XU Jun-Yu, LIU Wen-Ying Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China;RP-HPLC Determination of Telmisartan in Rat Plasma[J];Journal of China Pharmaceutical University;2003-03
4 WU Jie,FENG Fang,JIANG Juan-Juan,TIAN Yong (Department of Pharmaceutical Analysis,China Pharmaceutical University,Nanjing 210009,China);Determination of Telmisartan in Human Plasma by HPLC-MS and Study of Its Pharmacokinetics[J];Journal of China Pharmaceutical University;2004-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Yue-hui HE Pu-han (ShengJing Hospital of China Medical University,Shenyang Liaoning 110005 China);Research on Questions of Pharmacokinetics of Intravenous Injection Based on Control Model[J];Journal of Biomathematics;2007-04
2 LIU Mei-liang,LI Ming(Department of Pharmacy,Hunan Provincial People's Hospital,Changsha 410005,Hunan);Determination of Content of Telmisartan Tablets by RP-HPLC[J];Practical Preventive Medicine;2007-04
3 QIAN Yue-sheng~1,WANG Xian-yan~1,HUANG Gao-zhong~2,LU Feng-xiang~3,GENG Qi-ji~4,ZHOU He~5,ZHU Ding-liang~1(1.Shanghai Institute of Hypertension,Ruijin Hospital,Shanghai Second Medical University,SHANGHAI 200025,China;2.Shanghai Changzheng Hospital,SHANGHAI 200002,China;3.The First Affiliated Hospital of Nanjing Medical University,Nanjing JIANGSHU 210029,China;4.The Nanjing First Affiliated Hospital of Nanjing Medical University,Nanjing JIANGSHU 210006,China;5.Shanghai Qing-an Pharmaceuticals Limited,SHANGHAI 200135,China);Candesartan cilexetil in treatment of essential hypertension in 118 patients[J];Chinese Journal of New Drugs and Clinical Remedies;2005-11
4 XIN Qin,LIU Shan-ting,GE Shun,WANG Chuan-gong,ZHANG Xin,XU Hong-kai (Department of Pharmacology,Jining Medical College,Jining SHA NDONG 272013,China);Promotion effect of telmisartan on memory deficit induced by brain ischemic reperfusion in mice[J];Chinese Journal of New Drugs and Clinical Remedies;2006-09
5 KONG Yan,CHU Shao-li,CHEN Shao-hang,DU Jian,WU Shun-di,HU Ya-rong,ZHU Ding-Hang (Department of Hypertension,Ruijin Hospital Affiliated to Medicine School of Shanghai Jiaotong University,SHANGHAI 200025,China);Comparison of eprosartan and losartan in patients with mild to moderate essential hypertension[J];Chinese Journal of New Drugs and Clinical Remedies;2007-02
6 ZHANG Hui and FANG Ying - zhi (Affiliated Sir Run Run Shaw Hospital,Medicine College,Zhejiang University, Hangzhou 310016);HPLC/APCI -MS Determination of Telmisartan in Human Plasma[J];Chinese Journal of Pharmaceutical Analysis;2004-05
7 CAI Wenhua. Dept. of Cardiology Qianxi Hospital of Hebei Province, tangshan (064300);Effect and safety of Irbesartan and Hydrochlorothiazide combination therapy on essential hypertension[J];Chinese Journal of Pest Control;2006-09
8 WANG Xiao-hong,SUN Hong-liang,KONG Deng (Department of Basic-medicine Teaching,Weifang Medical College,Weifang 261042,China);Determination of telmisartan in human plasma by HPLC-fluorescence[J];China Medical Herald;2008-08
9 LIU Bao-lan~(1),LIU Sheng-you~2,YU Xiong-jie~2(1.The Eleventh Hospital of Wuhan,Wuhan 430022,China;?2.Wuhan Asia Heart Disease Hospital,Wuhan 430022,China);Utilization of Angiotensin Receptor Blockade(ARB) in A Heart Disease Hospital During the Period 2005~2007[J];Evaluation and Analysis of Drug-Use in Hospitals of China;2008-06
10 HU Chang-ju,HU Shi-ming;The Clinical Curative Effect and Safety for Irbesartan on Essential Hypertension[J];Guide of China Medicine;2008-13
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Sun Zhongshi (Navy General Hospital of PLA, Beijing 100037);A NEW AT-ANTAGONIST──TELMISARTAN[J];CHINESE NEW DRUGS JOURNAL;1999-12
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved