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《Northwest Pharmaceutical Journal》 2007-05
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Preparation of polylactic acid enveloped aspirin microspheres

XIAN Yuan-fang1,CHENG Feng-mei1,YU Bao-jie2(School of Chemical Engineering,Changchun University of Technology,Changchun Jilin 130012,China1 ;School of Bological Engineering,Changchun University of Technology,Changchun Jilin 130012,China2)  
Objective Polylactic acid enveloped aspirin microspheres were prepared by solvent evaporation method.Method The orthogonal test of 3 factors and 3 levels was applied to optimize the preparation procedure.The particle appearance,drug content,and rate of encapsulation were used to evaluate the preparation procedure.Results and Conclusion Microspheres in the range of 5~22 μm were obtained.The drug content was 7.25% and encap sulated rate was 39.5%,and t1/2(in vitro) was 70 h.The results showed the microspheres prepared dy the method had obviously release effect.
【Key Words】: aspirin polylactic acid emulsion-solvent evaporation method orthogonal tast release microspheres
【CateGory Index】: TQ463
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