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《Northwest Pharmaceutical Journal》 2017-01
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Domestic research progress on cholesterol-lowering agents

SUN Kangyue;LI Ying;LI Yueqi;YIN Xiaomao;Department of Hematology,the Third Affiliated Hospital of Xiangya Medical College,Central South University;  
Objective To introduce the research progress of cholesterol-lowering agents in China.Methods The literatures about the study of lipid-lowering drugs in animal or cell models were retrieved.Results Besides at present commonly used clinical lipid-lowering drugs,researchers explored the lipid-lowering effect of extracts from grape seed and rhubarb,etc,in order to get more safe and more effective lipid-lowering agents.Pomegranate peel polyphenols inhibited the gene transcripton of HMG-CoA reductase,which had the effects on blood lipid-lowering.Ezetimibe had inhibitory effects on both cholesterol 7α-hydroxylase(CYP7A1)and Niemann-Pick-C1-Like1(NPC1L1),so ezetimibe had either increasing or decreasing functions on regulating blood lipids according to its mechanism.The lipid-lowering effects of benzafibrate,eicosapentaenoic acid,and other agents were also reviewed in this article.Conclusion Research and application of lipid-lowering Chinese herbs had a promising future.
【Fund】: 中南大学创新创业项目(编号:ZY2015796)
【CateGory Index】: R972.6
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