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《Northwest Pharmaceutical Journal》 2017-02
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Optimization of formulation and preparation process of shikonin noisomes by orthogonal design

ZHUGE Ruijiao;YIN Yanming;YAN Haixia;WANG Shasha;QU Xiaolan;WANG Jianzhu;College of Pharmacy,Taishan Medical University;  
Objective To optimize the preparation technology of shikonin noisomes.Methods The shikonin noisomes were prepared by thin film hydrolysation method.The preparation was optimized by orthogonal design with encapsulation co-efficiency as index using the ratio of shikonin to Span-60,the ratio of Span-60 to cholesterol,the dosage of phosphate cushion fluid and the time of hydration as factors.The encapsulation efficiency was detected by HPLC.The morphological examination of shikonin noisomes was performed using microscopy.The particle size of the noisomse was measured.Results The ideal preparation parameters were as follows:the ratio of shikonin to Span-60 was 1∶20,the ratio of Span-60 to cholesterol was 1∶1,the dosage of phosphate cushion fluid was 15 mL and the time of hydration was 30 min.The noisomes with spherical or ellipsoidal shape and better stability featured the encapsulation efficiency of 81.6%,the mean particle size of 387.6nm,and the PDI of 0.476.Conclusion The preparation technology is feasible,stable and reproducible and could be used in industrial production.
【Fund】: 山东省中医药管理局发展计划项目(编号:2013255);; 泰安市科技发展计划项目(编号:201440774-16);; 国家级大学生创新创业训练计划项目(编号:201410439029)
【CateGory Index】: R283.6
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【Citations】
Chinese Journal Full-text Database 10 Hits
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【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 YE Shi-feng;CHEN Ri-lai;LI Yu-zhen;LIU Ni-ni;LIU Jun-bo;LI Hong-xia;Dept.of Pharmacy,Shenzhen Futian District Second People's Hospital;Dept.of Pharmacy,the Affiliated Futian Hospital of Guangdong Medical College;;Construction and Characterization of Tacrolimus Niosomes[J];中国药房;2015-34
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3 ZHOU Hua-geng;LIU Xiao-hua;FU Zhi-jun;Department of Pharmaceutics of Traditional Chinese medicine,China Pharmaceutical University;;Studies of the Optimum Extraction Process of Alkannin from Arnebia Euchroma(Royel) Johnst in Xinjiang[J];海峡药学;2015-07
4 CHEN Zheng;CHEN Wen-ming;REN Wei-qiong;LI Wen-li;Hunan Institute for Food and Drug Control;Department of Pharmacy,the First Hospital Affiliated to Hunan University of Chinese Medicine;;Comparative study of related quality of Arnebiae Radix from different market[J];中国当代医药;2015-10
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8 Zheng Wensheng,Wang Lulu,Zhang Yujia,Fang Xiaqin(Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing Key Laboratory of Drug Delivery Technology and New Formulations,Beijing 100050,China);Preparation and Quality Evaluation of Doxorubicin-loaded Proliposomes[J];中国药师;2012-08
9 JIANG Su-fang,ZHANG Xue-ping,ZHOU Xue-jun(Medical College,Hunan Normal University,Changsha 410013,China);Preparation and evaluation of paeonol self-microemulsifying drug delivery system[J];中成药;2012-05
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