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《Acupuncture Research》 1996-03
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Effects of Electroacupuncture at Du Meridian on Contents of Nitric Oxide and Endothelin in Rats with Acute Cerebral Ischemia

Xu Nenggui; Xu Gtlansun; Zhong Ping;Wang Lianfa; Zhu Shunli; Chen Quanzhu(Institude of Acuputncture and Merdisn, Anhui College of TCM, Hefei, 230038 )  
Thirty rats were randomly assigned to three groups, control group (10 cases), acute cerebral is-chemia group (10 cases) and electroacupuncture (EA) group (10 cases). The bilateral common carotidarteries were occluded, which caused sharp drop of regional cerebral blood flow and led acute cerebralischemia. Contents of nitric oxide (NO) and endothalin (ET) in the cerebral cortex and boold weredetermined in normal, during occluding and after EA of Du meridian (GV 20, GV 14) point in rats.It was found that in acute cerebral ischemia, the brain contents of NO and ET increased, the plasmelevel of ET elevated and serum level of NO decreased. After EA of Du meridian point, the levels of ETand NO in the brain and blood were returned significantly to normal. It is suggested that EA at Dumeridian have protective effect on neural damage induced by brain ischemia. NO and ET are possiblyinvolved in the regulative effect of EA.
【Fund】: 国家中医药管理局科研基金
【CateGory Index】: R246.6
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