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《Acupuncture Research》 2001-04
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Effect of Electroacupuncture on Immunoregulation of β-EP in Rats with Morphine Abstinence Syndrome

Song Xiaoge, Tang Zhaoliang, Zhang Fuqing, Chen Quanzhu, Hou Zhengming, Zhu Qingfeng (Acupuncture and Moxibustion Institute, Anhui College of TCM, Hefei, 230038)  
Objective: To observe the effect of electroacupuncture (EA) of"Zusanli"(ST 36) on the immunoregulating action of β EP in rats with morphine abstinence syndrome for studying the mechanism of acupuncture in dispelling toxin and reinforcing body resistance. Methods: A total of 24 rats were divided into control group (n=8), morphine group (n=8) and EA group (n=8). Rat morphine abstinence syndrome model was made by intramuscular injection of morphine (20 mg/kg for the first day, double, 3 times and 4 times for the following 3 days, and 100 mg/kg for the 5th ~8th day). EA (2 Hz ~100 Hz, 10 V, continuous waves) was applied to "Zusanli" (ST 36), once daily and continuously for 8 days. Serum IL 1, IL 2, β EP contents and β EP level of hypophysis were detected using radioimmunoassay.Results: The results showed that in comparison with morphine group, the rat body weight, spleen weight and thymus gland weight, β EP in serum and hypophysis, Serum IL 1 and IL 2 of EA group and normal group increased significantly (P0.05 ~0.001). There was a positive correlation between β EP of hypophysis and IL 1 in EA group. Conclusion: Results suggest that the effect of acupuncture in improving symptoms of abstinence symposium might be related to favorable regulation of β EP on cellular factors.
【Fund】: 安徽省教委自然科学基金项目;; 安徽省重点科研项目;; 合肥市科委重点科研项目
【CateGory Index】: R245.97
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